ID A0A3B1K3K6_ASTMX Unreviewed; 1112 AA.
AC A0A3B1K3K6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Integrin subunit alpha 7 {ECO:0000313|Ensembl:ENSAMXP00000049083.1};
GN Name=ITGA7 {ECO:0000313|Ensembl:ENSAMXP00000049083.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000049083.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000049083.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3B1K3K6; -.
DR Ensembl; ENSAMXT00000041475.1; ENSAMXP00000049083.1; ENSAMXG00000024694.2.
DR GeneTree; ENSGT00940000159891; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000024694; Expressed in heart and 11 other cell types or tissues.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF90; INTEGRIN ALPHA-7; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..40
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 41..1112
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017207996"
FT TRANSMEM 1049..1074
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 45..110
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 317..378
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 379..434
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 438..497
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 482..646
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 648..805
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 815..1041
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 896..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 906..939
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1112 AA; 122649 MW; 4937DA873377F421 CRC64;
MCREDSAMDL QSTHRRTAGL TGPLVLLVLL LLALTAPTSA FNLDTTDTLN KEGEVGSFFG
FSLALHQQLS PQPKSWLLVG APRARGLGAL RNSHPGALYR CPITAEEYDC ERVDIDGDVS
LDRESKDNQW LGVTVKSQGI GGKVVACAHL YELRQRVNQL SETRDPIGRC YMLSEDLTER
DDLDGGEWKF CEGRPQGHEQ FGFCQQGLAA SFTPDNNYVL FGAPGTYNWK GEMRVQQLNQ
TLIHMGFYDD GPYEVAGEKQ QNAMLIPLPY HSYLGFSVDS AKGIMSRGEL TFVAGAPRAN
HTGAVVLLKK DNVYRLVPEY ILWGEELASS FGYSVATTDL NSDGWTDLIV GAPNFFDRKA
EIGGAVYVFL NPASHWEKAR PIRLNGTYDS MFGMTVSSVG DLDQDGYGDV AVGAPFDGDG
KVFIFRGSAN GIDTKPSQVL DGLNAGVKRF GYSISGGLDI DGNLYPDLAV GSLSDQVVLY
RSRPVIHVVR DISLEPQPID LTQQNCQGRD GVCVRIEACY TYTAHPETYS PHITLSVHFE
ADTERRKLGL PHRVYFLGRA ASEPEYVHTK DLELRGQKHP ACQTATFVLQ ENIRDKLRPI
SLAITHTIKK TRHQGHFGDK HLGRLSPVLG VSLSNTYYSE VNFLREGCGE DKICQSNLKL
SYQFGTRAPT SDIFTPLPLD EDGVPVFSLS DQRSVVLEVT VSNTPSDPEN PQEDGDDAHA
AQMVVTLPST LSYSGFRGQQ VVCQANQNGS QAECELGNPV KRDAVLKFYI ILSTSAITIE
TTSLSVDLLM STISEQPGLT TVTAFAKVVI ELPLAVSGLA RPHQLFFSGE VRGESAMKTL
DDVGSEVEYE FMVTNTGPSV QTLGSAFLNI MWPHELANGK WLLYPSGLHI EGHPQTHCTP
KSALDPRGLR PKENHVQNLK ARRKTRSHPE EEEEEGKTMT KGGPPNTTPA VAASERRKSL
KLDCLLGSAR CVLLQCPLHS FSGSALFRIS ARLWNTTFIE EFSAVSALEL LVRANITVKS
SIKHLVLRDA AAQVPVMIYP EHGLSDQYWI PWWIILIAIL AGVLVLALLV CILWKCGFFK
RTERHPHFET EYYRAHLQLQ PSDADKQAAE LQ
//
