ID A0A3B1K433_ASTMX Unreviewed; 434 AA.
AC A0A3B1K433;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Acyl-coenzyme A thioesterase 4-like {ECO:0000313|Ensembl:ENSAMXP00000049397.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000049397.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000049397.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the C/M/P thioester hydrolase family.
CC {ECO:0000256|ARBA:ARBA00006538}.
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DR AlphaFoldDB; A0A3B1K433; -.
DR STRING; 7994.ENSAMXP00000049397; -.
DR Ensembl; ENSAMXT00000040046.1; ENSAMXP00000049397.1; ENSAMXG00000035728.1.
DR GeneTree; ENSGT01010000222336; -.
DR InParanoid; A0A3B1K433; -.
DR OrthoDB; 5356064at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000035728; Expressed in intestine and 8 other cell types or tissues.
DR GO; GO:0016790; F:thiolester hydrolase activity; IEA:InterPro.
DR GO; GO:0006637; P:acyl-CoA metabolic process; IEA:InterPro.
DR Gene3D; 2.60.40.2240; Acyl-CoA thioester hydrolase/BAAT N-terminal domain; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR016662; Acyl-CoA_thioEstase_long-chain.
DR InterPro; IPR014940; BAAT_C.
DR InterPro; IPR006862; Thio_Ohase/aa_AcTrfase.
DR InterPro; IPR042490; Thio_Ohase/BAAT_N.
DR PANTHER; PTHR10824:SF36; ACYL-COA THIOESTERASE 19-RELATED; 1.
DR PANTHER; PTHR10824; ACYL-COENZYME A THIOESTERASE-RELATED; 1.
DR Pfam; PF08840; BAAT_C; 1.
DR Pfam; PF04775; Bile_Hydr_Trans; 1.
DR PIRSF; PIRSF016521; Acyl-CoA_hydro; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 20..151
FT /note="Acyl-CoA thioester hydrolase/bile acid-CoA amino
FT acid N-acetyltransferase"
FT /evidence="ECO:0000259|Pfam:PF04775"
FT DOMAIN 214..424
FT /note="BAAT/Acyl-CoA thioester hydrolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08840"
FT ACT_SITE 242
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR016521-1"
FT ACT_SITE 334
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR016521-1"
FT ACT_SITE 369
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR016521-1"
SQ SEQUENCE 434 AA; 48110 MW; 5A3838E65690B435 CRC64;
MAGIRHCPLL SVRPLRCLVD EKFEVVVQFL LPSQPVTLHA LLQSEDGDFW EAFGHYKGDA
SGSVKVSEDV SLGGSYDGLE PMGLLWSMRP IPGSRKGLRF RNKDVFKPIE VHISVYEGHL
TKWFKEKQAL ASVVAERWYS SPGVQRIDVR EKGLKGTLFI PPGPGPFPAV LDLWGGGGGL
VEYRSALLAS HGYITLTLEY IGLKDASGTP QNVDNDYFEA AFSLLKQHPQ VCPDRIAMMG
LSFGVSVTLG MAAYSSEINP KCVVCVSGSH IMPVNGSLAD VFKEIKKNVK NTRYDEERRI
IWRDLLLPIP DDPSKKVEMG LIQCPILLIV GEDDQNWAAA ESAEDMKKMM EQAGNSHLLT
VLSYPHTGHL IEPPYCPHVR SSNFKLIEAK TTVVVVWGGQ MVPHSKAQED SWQKTLAFLE
QHLYTHDTVA SKSN
//
