ID A0A3B1K526_ASTMX Unreviewed; 1489 AA.
AC A0A3B1K526;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000049767.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000049767.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR Ensembl; ENSAMXT00000042113.1; ENSAMXP00000049767.1; ENSAMXG00000021796.2.
DR GeneTree; ENSGT00940000153617; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000021796; Expressed in camera-type eye and 6 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14553; R-PTPc-LAR-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 851..875
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..119
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 131..219
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 227..309
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 316..406
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 411..507
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 509..600
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 937..1189
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1109..1180
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1221..1480
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1398..1471
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 394..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1489 AA; 167300 MW; 7D33EF39A7291301 CRC64;
NYCGTIPGST SVLSPLQGFT SAERVSSPPR FTRTPTDQTG VQGGVASFVC QATGDPQPRI
SWSRKGKKVT NQRFEVIDFE DGSGSVLRVQ PLRTPRDEAV YECVASNEAG EISASTRLTV
LREDQLPTGF PSIDMGPQLK VVERSRTATM LCAASGAPDP EITWFKDFLP IDTHIHGRIK
QLRSGALQID RSEETDQGKY ECVATNSDGT RYSTPANLYV RVRRVPPRFS VPPMDYEIMP
GGGVNITCQA VGVPMPYVKW MLGTEDLTPE DDMPIGKNVL ELTDVRQSAN YTCVAMSTLG
VIETVAQITV KALPNPPGAP VIMERSATSI TLMWDSGNPL PVSYYIIQHR PTSSRDPFKE
IDAVATTRYS VGGLSPYSYY QFRVIAVNSI GRGPPSPTVE ARTAEQAPSS PPRRVRGRML
SVSTAMVQWE EPEEANGQVV GYRVYYTSDS SLPVSQWEKE MVRGANFLTI QDLTPNKTYY
IRVLAFTAVG DGPLSSDLHI IAKTGVPSQP TELKAEVKSE TSVLLSWFPP AHSGTDAITG
YELIYRLGDQ PEEKINFDPS SSYLLKNLKP FSTYTFQLAA RSKHGVGAFT GEVTVQTPQT
LFAVNFRVKA AMKSSVLLAW EPRTSQNKIT YGDSQTVEVD GRVGQKLVTK LKPQSLYTLL
LTNKADVTGG LQHRAEAMTA PNLMPSKPQL LEKTSAQSTA MLQLPSVEGQ ANVRLGFYIV
VVPLKRQRGG NFQNPWINWS VPISYLKSIV DIFTLLRSRS VRLRRQAELK PYISAHFQNL
PSEFKLGDGR VYGAFLNRPL LNGQEYVCFV LAILELGQNV SIPTVYSTSL FSDSVVFSDV
EPQPIVDEEE GLLWVVGPVL AVIFIISIVI LILLFKRYRG KEKITLDKAM SSQHPSDPVE
LRRINFPTPG MASHPPVAIS ELPNYIERMK ANENLRFSQE YESIDPGQQF SWEHSNLEIN
KPKNRYANVI AYDHTRVVLS NNDGSDYINA NFIDGYRRQG AYIATQGPMP ETISDFWRMV
WEQHTANIIM ITKLEEKSRN KCDQYWPSRG TETYGLMQVS VLDTVELATY CVRTFALFKS
GCSERREVRQ FQFTAWPDHG VPEHPTPFLA FLRRVKACNP PDAGPIVVHC SAGVGRTGCF
IVIDGMLERV KQEKTIDVYG HVTLMRSQRN YMVQTEEQYV FIYDALMEAV TCGNTEVPAR
NLYAYIQRLT QAEPPDNISG MEQEFKRLAN ARAHNSRFVS ANLPCNKFKN RLVNIMPYET
TRVSLQPIRG VEGSDYVNAS FIDGYRQQRA YIATQGPLAE TAEDYWRMLW EHNSTIVVML
TKLREMGREK CHQYWPSERS ARYQYFVVDP MAEYNMPQYI LREFKVTDAR DGQSRTVRQF
QFTDWPEQGV PKSGEGFIDF IGQVHKTKEQ FGQDGPITVH CSAGVGRTGV FITLSIVLER
MRYEGVVDIF QTVKMLRTQR PAMVQTEEQY QFCYRAALEY LGSFDHYAT
//
