ID A0A3B1K650_ASTMX Unreviewed; 320 AA.
AC A0A3B1K650;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 {ECO:0000256|ARBA:ARBA00039261};
DE AltName: Full=BTB/POZ domain-containing protein TNFAIP1 {ECO:0000256|ARBA:ARBA00041740};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000050137.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000050137.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Endosome {ECO:0000256|ARBA:ARBA00004177}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the BACURD family.
CC {ECO:0000256|ARBA:ARBA00025759}.
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DR STRING; 7994.ENSAMXP00000047743; -.
DR Ensembl; ENSAMXT00000031398.1; ENSAMXP00000047743.1; ENSAMXG00000030459.1.
DR Ensembl; ENSAMXT00000050019.1; ENSAMXP00000051484.1; ENSAMXG00000030459.1.
DR Ensembl; ENSAMXT00000055302.1; ENSAMXP00000050137.1; ENSAMXG00000030459.1.
DR GeneTree; ENSGT00950000183143; -.
DR OrthoDB; 2912088at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000030459; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR InterPro; IPR045068; BACURD1-3.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR PANTHER; PTHR11145; BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER; 1.
DR PANTHER; PTHR11145:SF17; BTB_POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN 2; 1.
DR Pfam; PF02214; BTB_2; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 40..140
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
SQ SEQUENCE 320 AA; 36336 MW; 4894837A43D413FC CRC64;
MSGESCLHQR PPQVPPTLLV SAVTCPKTKT CCQEGTVGNK YVRLNVGGVL HYSTVQVLTR
QDGLLKSMFS GKTEVFTDKE GWILIDRCGK HFGSILGYLR DGSLTLPKSR QGIMELLAEA
KYYHIQGLID LCQQAVQDNK QQALCVIPVI TSSKEEERLI QGCTRPVVKL LYNRSNNKYS
YTSNSDDNLL KNIELFEKLS LSYNGRVLFM KDVIGDEICC WSFYGQGRKL SEVCCTSIVY
ATEKKQTKVE FPEARIYEET LNALLYETLP VPDNSLLEAT RRRAHCGSHS EEEEGVELRE
RVRHIHIKRY STYDDRPLGH
//
