ID A0A3B1K697_ASTMX Unreviewed; 925 AA.
AC A0A3B1K697;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=NLR family CARD domain-containing protein 3-like {ECO:0000313|Ensembl:ENSAMXP00000050023.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000050023.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000050023.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
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DR AlphaFoldDB; A0A3B1K697; -.
DR STRING; 7994.ENSAMXP00000050023; -.
DR Ensembl; ENSAMXT00000054851.1; ENSAMXP00000050023.1; ENSAMXG00000041565.1.
DR GeneTree; ENSGT01100000263573; -.
DR InParanoid; A0A3B1K697; -.
DR OrthoDB; 5362465at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000041565; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 5.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 10..76
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 204..337
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 421..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 925 AA; 102886 MW; AFA05E508FE56883 CRC64;
MALGPCSLDL QKRRVELVRD WSKHISSLLD LLFNMGTVTE EDLSLIRGGG HTGELDCMRT
LLDVLQGRGE EACRAFQFVL SNFKTSTASE TGKAKLFPQN THNMQKVLKE GLQKHKDILA
KHHGPVLSSY LSSARQTSRS AEVDTFTDIT FCRQVGYPVP LQYQHEATVV GDSFRASRDE
AKRRGQTCAF RELYQSLLCV SEDGVALLSG VAGSGKTTVI KRLVQQWAAD VDAQKIVLSM
SFRELSLITE PQSLQGLLSD HYSHLKPVLP ELLTSTQGQV VLILDGLDEF CFPLDFERTP
KCSDPERELS VGALVVNLIK GNLLPGTSIL LTSRPHAVAK VPQLLVRQFY SVLGFSPAQQ
KQYFEQNCSS SQAAATVWSF VSSHKPIQLM CHIPAFCWIV STALHEGTSC LFFDTVQTGA
ASQENGSDST KEVSGAECSD QSSSDPNALL ANGPAAQSVC RPTTVTEIYC CFLKSIVVFH
VGGCMEGMHL NRLQDAPRVL RENKGMLRCL GALAFRGLLE RRFVFDLSDL SSFSLDSCEL
TQAFTVEVLK EDKASLTYEK SFHFIHTSVQ EFLAALYYML ESFSGSDPFS GLKPAVPALH
KHLMSFVNKL RRPKRVLHKR VKKAFRCGES HQSGHMDLFC RFVSGLFVPK TRFILDGLFS
GEHRPRLASC MNLPSVSPPF VVKLLRSQLH SSSLSPERQL NICHCLYEAQ DSELSLHLQH
WLTVLSQQTS GQCALLNRDW SELAFLLQLC PDLQQLKLDA QELDAVGLRR LLPVLPLFST
LSLAQNPLGP EGAEVLSLAL RSPDCQIEHL WVVSTDLGCE GFRNLAEGLK DNRTVFDLRM
AINHIGDTGA ACLAELLKTN RTLRDIRLRD NLVTDSGAEL LMEALTENTT LEYLWLFDNK
LSKECVQKLK EFSKSRSTLD IKVCF
//
