ID A0A3B1K7N7_ASTMX Unreviewed; 785 AA.
AC A0A3B1K7N7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000050687.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000050687.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007232883.1; XM_007232821.2.
DR AlphaFoldDB; A0A3B1K7N7; -.
DR Ensembl; ENSAMXT00000034115.1; ENSAMXP00000050687.1; ENSAMXG00000006118.2.
DR GeneID; 103023523; -.
DR CTD; 57144; -.
DR GeneTree; ENSGT00940000158656; -.
DR OMA; KSHPQGH; -.
DR OrthoDB; 460351at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000006118; Expressed in camera-type eye and 9 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01093; CRIB_PAK_like; 1.
DR CDD; cd06658; STKc_PAK5; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033923; PAK_BD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR028754; STKc_PAK5.
DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR PANTHER; PTHR48015:SF27; SERINE_THREONINE-PROTEIN KINASE PAK 5; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00285; PBD; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 61..74
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 515..766
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 146..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..463
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..485
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 545
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 785 AA; 87568 MW; B99F0E9A0B1AE970 CRC64;
MSCQDFAVMS GIMTAGLLQH VSSQCLDWGF RDQASALKMK TESGLSSFSN MFGKKKKRLE
ISAPSNFEHR VHTGFDPREQ KFTGLPQQWQ SLLADTANRP KPMVDPSYIT PIQLAPMKTI
VRGNRPPKDA SINGLLEEFD SISVTRSNSL RKESPPGAHQ AGSSKQPSVA SANASSSGGP
EENGFGHYYA RYSCDLDSSR EFSLDPYRDK GGYDGEWAVG RHYRFSVKQN GHPVRSPFYP
DAMPQKASDY AKMPPDYHAY LESKVHLSAD EMGARGSRDY YRASLGGSSQ DYLGTPSRAS
LHSEQMSYQD GDWVGGAYGP GLRDDYEKRP KSSYISQTSP QPAIRQRSRS GSGLQEPSLP
YGISAFKAAP QGPYSSYTYP RLSENTSASQ IIGKSDYDRM SRDGSPQVPG AETYPRGPLK
LPQSHTKPGY PPSFQYPPAF HYKPSPYHHP PTQPSPPYTP QGAHSQPSSP YIPPGAYPPP
SWGSSSEQPP SRVSHEQFRA ALQLVVNPGD PREYLDNFLK IGEGSTGIVC IATEKHSGKQ
VAVKKMDLRK QQRRELLFNE VVIMRDYHHE NVVDMYNSYL VGDELWVVME FLEGGALTDI
VTHTRMNEEQ IATVCLSVLK ALSYLHTQGV IHRDIKSDSI LLTSDGRIKL SDFGFCAQVS
KEVPKRKSLV GTPYWMAPEV ISRLPYGTEV DIWSLGIMVI EMVDGEPPYF NEPPLQAMRR
IRDNLPPRLK ESHKVSSVLR AFLDLMLVRE PSQRATAQEL LQHPFLKLSG PPSCIVPLMR
HYRHR
//
