ID   A0A3B1K8E4_ASTMX        Unreviewed;       872 AA.
AC   A0A3B1K8E4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000050733.1, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000050733.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B1K8E4; -.
DR   Ensembl; ENSAMXT00000054814.1; ENSAMXP00000050733.1; ENSAMXG00000043459.1.
DR   GeneTree; ENSGT01100000263547; -.
DR   InParanoid; A0A3B1K8E4; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000043459; Expressed in pharyngeal gill and 13 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR029495; NACHT-assoc.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR   Pfam; PF14484; FISNA; 1.
DR   Pfam; PF13516; LRR_6; 3.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   SMART; SM01288; FISNA; 1.
DR   SMART; SM00368; LRR_RI; 4.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS51450; LRR; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT   DOMAIN          100..234
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   REGION          58..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..76
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   872 AA;  98982 MW;  582D689126FC843F CRC64;
     FISLVKNELN TFKKLLSPDY PACSEREEED EDDQSEGVLK ITLHILRKMK EKDLANTLES
     RSGEVNNEHE VRQIEAASRR PATQETPIKC NDLFKDQSIR TVLTKGVAGI GKTVSVQKFI
     LDWTEGKANQ DVPFIFPLPF RELNLMKTEK LSLVDLLHQF FKDTKYLKKR DYHRYKVIFI
     FYDLDECRLP LDFQNNKRVS DITQSASVDV LLTNLIQGNL LPSALLWITT RPAAANQIPP
     ECIDHVTEVQ GFSHPQKEEY FRKRIRDQSL AERIITHMKS SRSLYIMCHI PVFCWISATV
     LERMLGEAEG GEIPKTLTQM FTHFLIFQIK HRSQKYQRES DVDLDQTREI ILTLGKLAFQ
     QLEKGNLIFY EEDLRECSVD VREVSVYSGV CTQIFRQESE LHLGKVFSFV HLSVQEFLAA
     LYVFLSFMSN NTNVLSGFLD FFKKVTMSDF LKRAVDKALQ SENGHLDLFL RFLLGLSLES
     NQTLLRGLLI QTENISHSKE EVVEYIKQKI RENPSPEKTI SLFHCLNELN DHSLVQEVQK
     YLNRGRSSDL SGVTLSSAQW SAVAFVMLNS EEELDEFDLR KFQRSEESAL LGKKALCLLA
     SEIRWNVQLM TCSDKVCSSV RPYCLEWSAH CNESPQSIYK ARRIHGLYDF YMDCSLAGCN
     LSEKSCADLA SALSSNSSTL RVLDLSHNNL QDSGVKLLSA GLKNPHCKLE KLEKNTPPHQ
     GKHPLSGTCT HCLLGFKFFL HIGTKNGNTQ DSVVSSGGCW SFKEGNCADL ASALSSNYST
     LRELYLSNNE LQDSGVKLLS AGLKNPHCKL KKLGLNYCSI TEEGCAALAS ALKSNPSHLR
     ELDLSFNEPG ESGEKLLSDL QKDPHFKLET LQ
//