ID A0A3B1K910_ASTMX Unreviewed; 708 AA.
AC A0A3B1K910;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=CBFA2/RUNX1 partner transcriptional co-repressor 3 {ECO:0000313|Ensembl:ENSAMXP00000050129.1};
GN Name=CBFA2T3 {ECO:0000313|Ensembl:ENSAMXP00000050129.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000050129.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000050129.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B1K910; -.
DR STRING; 7994.ENSAMXP00000050129; -.
DR Ensembl; ENSAMXT00000039470.1; ENSAMXP00000050129.1; ENSAMXG00000010859.2.
DR GeneTree; ENSGT00950000183176; -.
DR InParanoid; A0A3B1K910; -.
DR OrthoDB; 5314634at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000010859; Expressed in camera-type eye and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 6.10.250.230; -; 1.
DR Gene3D; 1.20.120.1110; TAFH/NHR1 domain; 1.
DR InterPro; IPR013289; CBFA2T1/2/3.
DR InterPro; IPR014896; NHR2.
DR InterPro; IPR037249; TAFH/NHR1_dom_sf.
DR InterPro; IPR003894; TAFH_NHR1.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR10379; MTG8 ETO EIGHT TWENTY ONE PROTEIN; 1.
DR PANTHER; PTHR10379:SF6; PROTEIN CBFA2T3; 1.
DR Pfam; PF08788; NHR2; 1.
DR Pfam; PF07531; TAFH; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR PRINTS; PR01875; ETOFAMILY.
DR SMART; SM00549; TAFH; 1.
DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1.
DR SUPFAM; SSF158553; TAFH domain-like; 1.
DR PROSITE; PS51119; TAFH; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT DOMAIN 156..251
FT /note="TAFH"
FT /evidence="ECO:0000259|PROSITE:PS51119"
FT DOMAIN 586..622
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
FT REGION 1..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 525..567
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..339
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..708
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 708 AA; 77460 MW; 246837B6BF560376 CRC64;
MTTELHRDRH RRSGRLSSSS SSSSSSSGVL MAQRVATVML TSQRRHTQRM PLTNHTQRRR
HTGSIEPKVG TMPDSPADVK TQPRSTPPTM PPPPPAVSQA ANRNASFTPT TMLNGSSHSP
TALNGAPSTP NGFSNGPASS STGSLPTQQL PPACGARQLC KLKRFLTTLQ QFGNDISPEI
GERVRSLVLG LVNSTLTIEE FHSKLQEATN FPLRPFVIPF LKANLPLLQR ELLHCARMAK
QTPAQYLAQH EQLLLDANAS SPLDSSEILL ELNEHGKRRT PDRTKDAAAE RDGLHAEHLA
KRPCTVSPSQ RFSPSSGLAA HAPPNGLPTH PPNGLHPTPP GPQQYRLEDM ALAHHYRDAY
RHVEHREARE RHRQTAVHGA RQEEVIDHRL TDREWAEEWK HLDNLLNCIM DMVEKTRRSL
TVLRRCQEAD REEMNHWIRR YSDVEDMKKG GGSAQRPLHH QHKPSSPPNS TNGSEPQHID
IHRDFLHRPP SGYLPEEIWR KAGAPSIPLS PALKQLHSKQ EEAVNEVKRQ AMSELQKAVG
EAERKAHEMI SAERSKMERA LAEAKRQASE DALSVINQQE DSSESCWNCG RKASETCSGC
NTARYCGSFC QHKDWEKHHH VCGQGLQGLP GSSSGVPLGA GTPSSSSTSN SSSSSSSSIP
PTHSESNPPG PLSLAGAASS PKDAGSGSSS ASRSTTPATP ALLDSSSR
//
