ID A0A3B1KD28_ASTMX Unreviewed; 1174 AA.
AC A0A3B1KD28;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Neurofascin-like {ECO:0000313|Ensembl:ENSAMXP00000051599.1};
GN Name=NFASC {ECO:0000313|Ensembl:ENSAMXP00000051599.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000051599.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000051599.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR AlphaFoldDB; A0A3B1KD28; -.
DR STRING; 7994.ENSAMXP00000051599; -.
DR Ensembl; ENSAMXT00000057010.1; ENSAMXP00000051599.1; ENSAMXG00000018756.2.
DR GeneTree; ENSGT00940000157024; -.
DR InParanoid; A0A3B1KD28; -.
DR OrthoDB; 2912783at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000018756; Expressed in bone element and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR CDD; cd04978; Ig4_L1-NrCAM_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF12; NEUROFASCIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1174
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017335464"
FT TRANSMEM 1029..1050
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..130
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 148..217
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 237..325
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 330..417
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 423..511
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 513..600
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 607..707
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 712..808
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 813..917
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 921..1017
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1137..1174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1159..1174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1174 AA; 133708 MW; BE2D32CA0A28629B CRC64;
MRTQRWWEFL ATFTLLLLIW RVDSIMEIPP NVRQPPMIIK QSVQDHIVEP TDPIIVECEA
TGNPPPVFTW TRDGVYLNVA RDPQVSMKRR SGTLEIFFWG RPEDYEGMYQ CTATNEFGSA
VSSHIHLRVS KARTWLKEYL EPVSVFVGLP LILPCNPPVG PPKPQTYWMN SSMVPIRQDR
RVSMGENGDM YFSSIVAEDA LTNYVCTARF PNSNTIQQKP PLILQVHTAR MAAQIAPKFM
KPKGTASSQI GMLGEELVLE CFASGVPAPS IKWTKDWEPL SMDGMKLENF NKTLRIKKIS
MDDGGEYICT ASNRMGYLDH IITVRVKSTP FWVQKPESLV LSRDDGGQIE CQADGIPRPR
IQWLVNGEPI EDAPKRADRQ VSGDTLTFRS VVPDSSAVFQ CNASNPYGYI LANAFLAVMD
MKPRLLGFRN QLVKVTEGSQ TLLHCPYFGS PKPDLRWSKG GMGSLEGGRF KVLSNGTLEI
RRTKLQDQGT YVCSASNVIG REEMDVQLEV KEPTKILRAP HNVIVIKGSL ARFECKFQTD
STLDVTVTWL KDKKFLILGR RMTKDEDSLT IADVYRRDEG VYTCRVKTEV EDVSVSAKLT
VMDRPDPPTD LEVSDPYERS ARLTWIPGDS HHSPIKEYLV QYTEDLLADY WLVQSGWKNL
TSYPGHLNSV VLKLMPFVEY RFRVIAINGI GPSRPSRPSE YYETGGAVPD AIPKNIKGVG
TGIFRNNMEI SWEPLEYREW NGPKLGYMVW WRRRDSREEW KNYTTYWWCS HIIYETDTFT
PYEIKVQAVN YFGLGPESPI IIGFSGEDRP TAAPDDLRVS DVESTKLTVH WQPVPQASIN
GDIKEYTVYY WRESSRLPHH TVSIRIKSKS FKANGPRLSG PLTGLIPYSN YMMYIVVANN
RYEGPPSNRI GFQTLEGVPS VPRSFRIMHR HYDTLYVDWE EPAEPNGILI GYTLKYQTLN
VSGERMQVEN LPPNATSFSL RRFDRYTRYK FSLAAQTQIG VGEVVTGESP HFTTEEFTRE
QVDIATQGWF IGLMCAIALL VLIMLTVFFI KRSRGGKYPV RAKRDFALGP LDDKEEGTFD
YRSLERITRL STLPYSRREE ESRQGRSQGT IEHMQKMTNS DDSLMEYGEG DEIEFNEDGS
FIGEYTGTSK RDRDSSQYQE SSEATSPVAI YSFA
//
