ID A0A3B1KDW7_ASTMX Unreviewed; 82 AA.
AC A0A3B1KDW7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Hematopoietic cell signal transducer {ECO:0000256|ARBA:ARBA00018050};
DE AltName: Full=DNAX-activation protein 10 {ECO:0000256|ARBA:ARBA00031263};
DE AltName: Full=Membrane protein DAP10 {ECO:0000256|ARBA:ARBA00031053};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000051894.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000051894.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DAP10 family.
CC {ECO:0000256|ARBA:ARBA00006724}.
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DR AlphaFoldDB; A0A3B1KDW7; -.
DR STRING; 7994.ENSAMXP00000051894; -.
DR Ensembl; ENSAMXT00000053384.1; ENSAMXP00000051894.1; ENSAMXG00000034223.1.
DR GeneTree; ENSGT01030000235489; -.
DR InParanoid; A0A3B1KDW7; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000034223; Expressed in intestine and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IEA:InterPro.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:InterPro.
DR GO; GO:0050776; P:regulation of immune response; IEA:InterPro.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR009861; HCST.
DR PANTHER; PTHR21409; HEMATOPOIETIC CELL SIGNAL TRANSDUCER; 1.
DR PANTHER; PTHR21409:SF1; HEMATOPOIETIC CELL SIGNAL TRANSDUCER; 1.
DR Pfam; PF07213; DAP10; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..82
FT /note="Hematopoietic cell signal transducer"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017307968"
FT TRANSMEM 37..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 82 AA; 8962 MW; 6292503BF0AC9FA8 CRC64;
MAYTVMLMMG FLSVVVMQCS AEETEKGSCY RIAPGTLAGA VLGDIALTIF IVGVTYCCAS
KRRQKKENAE KVYMNVRANC KP
//
