ID A0A3B1KG36_ASTMX Unreviewed; 1754 AA.
AC A0A3B1KG36;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Tetratricopeptide repeat domain 6 {ECO:0000313|Ensembl:ENSAMXP00000052985.1};
GN Name=TTC6 {ECO:0000313|Ensembl:ENSAMXP00000052985.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000052985.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000052985.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSAMXT00000054718.1; ENSAMXP00000052985.1; ENSAMXG00000000300.2.
DR GeneTree; ENSGT00940000161150; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000000300; Expressed in testis and 5 other cell types or tissues.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 9.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR013105; TPR_2.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44858; TETRATRICOPEPTIDE REPEAT PROTEIN 6; 1.
DR PANTHER; PTHR44858:SF1; UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED; 1.
DR Pfam; PF13432; TPR_16; 2.
DR Pfam; PF07719; TPR_2; 2.
DR Pfam; PF13174; TPR_6; 1.
DR Pfam; PF13181; TPR_8; 3.
DR SMART; SM00028; TPR; 22.
DR SUPFAM; SSF48452; TPR-like; 4.
DR PROSITE; PS50005; TPR; 12.
DR PROSITE; PS50293; TPR_REGION; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 776..809
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 844..877
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 946..979
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1015..1048
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1084..1117
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1299..1332
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1333..1366
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1367..1400
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1438..1471
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1577..1610
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1611..1644
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1679..1712
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..523
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..622
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1754 AA; 198490 MW; 787E5A409C98DC0C CRC64;
MKRNINPNVS TSEKTSPKLG SGQEAVKTPA IASLAGTARL VSLSKRPQPP AKPRSEKPST
AGGAFKNQTP SEQLSGEKKQ APRNQGQYLT VLDRCCLLNS SSSDEITVDR NEYEQDRRKC
RKESEKKRRQ LTDRQQEERA SKEHSSGSSK SSSATSTIRS IKSVTELLEE ARNIATGGLQ
EIHHQRVTEK AVSDMMKQES GHTVNDQMTK CGDLHTSEPG VREHVVFDIS DKQVRSHQDV
LEGIREEKIP AGTMNHAPDL TRSCKVTGLE ALGSSFLPVQ RPQRALQQTR TLHGLSLLAT
WTPKTDSGEY KTIHHLCTTP ACQVLPVELQ LASRMYHTQD LFITTTQFLQ QRTAFRQIAA
HPDSQWILWN GVPVENVGDT EQTGGITQLP PQSSDALEEW QKIAEYYVEK PRMILCGHAA
TLCDGQLRMF WSPAPPKFSS APNVVKDALF PHYQVTPADL SGENFLAGLQ AEMESGNDQM
EKKPRGLLEN ILSRKHKSLM DLRAEELVSE PSPEDHHEQQ LKRPFSSPHF LPASESPLRL
QSDFTSISRE LDRVRQQPQS PIYTQSNSML SASQAQSQNT RNKPTSPEKL SWDPSHSVSQ
HSRVRPKRVL GKSIKKKKSH KSSKLAYVHK KLKELPETLT RSVSSCELSQ IHKVSAEQTL
LLRFPSLPLL LDFDGFAVEQ GGIPVMLSHQ EWVGDIWNTW FDEVFPPQDH SSTKSEPEAR
QMQPVSNKQL KKKKEIPILD KVDLSEALDE GFTVEDLEME VAKLTESMIK NTGNNGFDLC
RRGALYKKLG LLKQALDDLN AAISLEPHLL DAYWHRHSIS LLRNAPNSAL DDLNFIIKHN
KKHADAFRSR AEIYRMRGET RLAILDYTQV IKNKPDDAEN YFRRADLYEK TNEISLAMED
YAKTFAINLE RTDALMAHAL HHFHTSVWRV ALDDFSLLLK QEPANARART YRGRTFAKLG
LFKEAIEDFC LAVHLDPRDW LAFYHRGCLL RRILPDVALR DLSVSVLING SSENLAAFLY
RGLLYTEQQQ WQKAMADFKA VIKIDRTVAA AHINLGLIYM LKMNQSQKAI RRFSNAIKAD
PTNIKGYVCR ARAYHNVNDL KRALKDLTRA LHLRPDDQYL HIMRGQCLCN MEQTALATFC
IQYSAEMKKA LGLTLVQQAA VQSFLQNDAK AIACLVSAAN SCPSPSILIL LGKTQLKVHK
FMEAVESFKK ALSFLNPKKT NICNVPEAPE LYYLTGVCYM AQGEDSLLPQ ALEAFSKATR
INPDYAEAYH QRGLCRIRLQ HSNSVQDFNR ALCINPNFYQ AYLSRAALYG AKGLYNKAIF
NCSEALKIQP KNVKAYLYKG ALKFYLKEYK KAVEDLTVAI EIDSSCSLAY YNRGVCYQVL
QEYKLALRDY STVLLLPEQK EIEFKVLINR TLVHKELNDH YNALQDLKAA ASKQPKDASL
FHSLGLYFHR LGQLQEAVEA YSEALRLSPF LLNAYVGRGN AFMDYGHSQG YKQAQRDFLS
ALHLNPRCSS ARIGLAYNLQ VFGCFQRVWN QFTVAVEVNP KCWAAYEGRA IVNLQMGNTY
AAFQDINNAL KCNPHSDQLL TNRGVINQFM GDKVSAMSDY QRAISLNPTC ALAFFNAANL
YFYNRQFEQA CEYYSRAIEL DPSDESPVLN RAISLALLQK IPESLQDFSE ALRLCPYSAH
IYFNRANLYH SLRKYKAAER EFTQALQLQP DDALLYKLRA DVRGHLGLME EAVKDYRTAV
ELQDSIQRPD SFSR
//
