ID A0A3B1KG42_ASTMX Unreviewed; 146 AA.
AC A0A3B1KG42;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 {ECO:0000256|ARBA:ARBA00040285, ECO:0000256|RuleBase:RU363103};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000052846.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000052846.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000256|ARBA:ARBA00003195, ECO:0000256|RuleBase:RU363103}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000256|RuleBase:RU363103}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000256|RuleBase:RU363103}; Peripheral membrane protein
CC {ECO:0000256|RuleBase:RU363103}; Matrix side
CC {ECO:0000256|RuleBase:RU363103}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA12 subunit family.
CC {ECO:0000256|ARBA:ARBA00007355, ECO:0000256|RuleBase:RU363103}.
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DR RefSeq; XP_007243383.1; XM_007243321.2.
DR AlphaFoldDB; A0A3B1KG42; -.
DR STRING; 7994.ENSAMXP00000052846; -.
DR Ensembl; ENSAMXT00000044941.1; ENSAMXP00000052846.1; ENSAMXG00000031707.1.
DR GeneID; 103030107; -.
DR KEGG; amex:103030107; -.
DR CTD; 55967; -.
DR GeneTree; ENSGT00390000005848; -.
DR InParanoid; A0A3B1KG42; -.
DR OMA; PRKFIWT; -.
DR OrthoDB; 821at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000031707; Expressed in muscle tissue and 14 other cell types or tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:InterPro.
DR InterPro; IPR007763; NDUFA12.
DR PANTHER; PTHR12910:SF2; NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12; 1.
DR PANTHER; PTHR12910; NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2; 1.
DR Pfam; PF05071; NDUFA12; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|RuleBase:RU363103};
KW Membrane {ECO:0000256|RuleBase:RU363103};
KW Mitochondrion {ECO:0000256|RuleBase:RU363103};
KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU363103};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Respiratory chain {ECO:0000256|RuleBase:RU363103};
KW Transport {ECO:0000256|RuleBase:RU363103}.
SQ SEQUENCE 146 AA; 16832 MW; F9108748A862DCE7 CRC64;
MGEYLNIVRR AAGQITGHGG VRGLLLQLFR VNDLKTGALI GVDKYGNKYY EDNRYFFGRH
RWVVYTTEMN GKRTMWDVDG SMVPAEWHRW LHCMTDDPPT THPPEPKKFL AKVHQINVSG
SSECYVPYST TPKKIHEWVP PKVGQQ
//
