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Database: UniProt
Entry: A0A3B1KHW6_ASTMX
LinkDB: A0A3B1KHW6_ASTMX
Original site: A0A3B1KHW6_ASTMX 
ID   A0A3B1KHW6_ASTMX        Unreviewed;       773 AA.
AC   A0A3B1KHW6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Chloride anion exchanger {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Solute carrier family 26 member 3 {ECO:0000256|RuleBase:RU362052};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000054297.1, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000054297.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Mediates chloride-bicarbonate exchange with a chloride
CC       bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a
CC       role in the chloride and bicarbonate homeostasis during sperm
CC       epididymal maturation and capacitation.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|RuleBase:RU362052}.
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DR   AlphaFoldDB; A0A3B1KHW6; -.
DR   STRING; 7994.ENSAMXP00000054297; -.
DR   Ensembl; ENSAMXT00000053531.1; ENSAMXP00000054297.1; ENSAMXG00000004041.2.
DR   GeneTree; ENSGT01070000253775; -.
DR   InParanoid; A0A3B1KHW6; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000004041; Expressed in testis and 2 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR018045; S04_transporter_CS.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF19; CHLORIDE ANION EXCHANGER; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS01130; SLC26A; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU362052};
KW   Chloride {ECO:0000256|RuleBase:RU362052};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        95..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        124..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        148..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        195..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        230..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        268..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        297..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        384..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        421..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        479..510
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          534..727
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
SQ   SEQUENCE   773 AA;  85421 MW;  09FE51F943B9A6C1 CRC64;
     MHFQFQTHFI PNTTESLTSG GLKMRTPVDQ YVVSRPLYTE DSFTENHEKV ERKHKTTLDH
     VKQYFTCDSK RVKNAALSLV PIVGWMKMYR VKEWLLGDIV SGVSTGLVAI LQGLAYSLLA
     SLPAWYGLYA AFFPVIIYFF LGTSRHISVG AFPVLSLMVG AVVTRMVPDG GPTVNITGLE
     GLSIDDQRAM VSASLTFLIG IFQLGMGLLQ VGFVVIYLSD TLVSGFTTAA AVHILISQLK
     FIFGLSVPGF SGPLILESIF TQITSTNIHD LVTAIVVMVV VFAVKEINER FKSKLPVPIP
     IEVIMTIIAC GVSYAFNFKD NHGVDVVGLI PDSFETPVAP NIEVFKETAV DAFPMAIVGF
     AISFAVAKVY AVKHDYVIDG NQELIAFGVS NIFGGAFKSL ASSTALSRSA VQESTGGKTQ
     IAGILSAIIV LIVTLAIGFL LEPLPKSVLG AVVIVNLKGM LMQMREVPYL WKKDRLDCII
     WIVTFLASIF LGLDLGLAVG LGVELLAVVF RTQFPRCSVL ANISGTDIYR DRKDYINIYE
     PEGVKIFRIP APIFFANIDF FRGKLLDAVG FNPLRILRKR NKALRKIRKL IKKGELSVTI
     KGLQVTGSYP IEESEDETNT EELDQPVDFS DLPVQVNWRA ELPANISVPP VDIHSLVLDF
     SAVSFIDISA LKGLKTALKE FIRIDVEIYI VACDPYIIEK LKSCSFFDHE IKTSIFFVTL
     HDAMLHILER HPPLSVYNNY PDKMPNSSSN LRSREKIVSK VDYLCLCVVS YLP
//
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