ID A0A3B1KIA8_ASTMX Unreviewed; 765 AA.
AC A0A3B1KIA8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Solute carrier family 35 member B4 {ECO:0000256|ARBA:ARBA00041931};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000053596.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000053596.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC subfamily. {ECO:0000256|ARBA:ARBA00010694}.
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DR AlphaFoldDB; A0A3B1KIA8; -.
DR Ensembl; ENSAMXT00000043251.1; ENSAMXP00000053596.1; ENSAMXG00000017675.2.
DR GeneTree; ENSGT00390000002915; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000017675; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0061617; C:MICOS complex; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR007964; MIC19/MIC25.
DR InterPro; IPR013657; SCL35B1-4/HUT1.
DR PANTHER; PTHR10778; SOLUTE CARRIER FAMILY 35 MEMBER B; 1.
DR PANTHER; PTHR10778:SF4; UDP-XYLOSE AND UDP-N-ACETYLGLUCOSAMINE TRANSPORTER; 1.
DR Pfam; PF05300; MIC19_MIC25; 1.
DR Pfam; PF08449; UAA; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 319..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 563..613
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 642..676
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 379..393
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..493
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 765 AA; 84201 MW; 3299304324998462 CRC64;
MNTAFAVSLV FAGCCSNVVF LELLVRKFPG CGNIVTFAQF AFIALEGFVF QTNFGRKKPA
IPISNYVIMV TMFFTVSVIN NYALNFNIAM PLHMIFRSGS LIANMILGII ILKKRYSASK
YLSIVLVSIG IFICTIMSAK QVSAQKGSTD EDGVYTFLQW LVGICMLTFA LLMSARMGIF
QETLYKQYGK HSKEALFYNH CLPLPGFLLL STNIYNHAVF FSQSTPVEIP LIGQHVPVMW
VYLLMNVITQ YVCIRGVFIL TTECTSLTVT LVVTLQGPAD RRFTHNMGGN SSSRLEDEEV
ITVVKGIRLT DRVIDRMKES PKAAKQRPQS NKQAHPPLNL GVPWSPTEPL GHILPHHPSY
ASSLVTPPLQ VPVPFASVSQ ETPAPPPPAA PSTVPTVEAV LSSPSSQESA ATSQHTDSLR
GTTAVPAGTG VTPPSSHDES IVPPATTEST AVPVEPFPTN TLAEEIAASK TPSPDAPFTA
PAPVPPPPVT AESVEELAPP QSSSTLVLPS ELPFMGQRGP TPTEETSAPQ ASAPTAEPDV
LSMLTPLTDT LTPLASPSSP QAVVNEEELR KQIRDELQKQ LEEEMKTAKL KIQQQLEEEK
AKAEAEVQKV LEGEQQALQQ SLKDAIMQER MNTEDERLVA QYYWMERKIQ KVEEREKQLE
KQDILYRNQI TKLEEKVRNN ISLAHTTSLF SNQSNESSIR FNNQHTGNIL MLLVYVFHCS
PYVHGLTRIP VSLSHHADCT VHQSYSRKLQ KGFGGHSQSL QVSQP
//
