ID A0A3B1KIL4_ASTMX Unreviewed; 1582 AA.
AC A0A3B1KIL4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Kinesin family member 20Bb {ECO:0000313|Ensembl:ENSAMXP00000053696.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000053696.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000053696.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR Ensembl; ENSAMXT00000054879.1; ENSAMXP00000053696.1; ENSAMXG00000007718.2.
DR GeneTree; ENSGT00940000155989; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000007718; Expressed in embryo and 10 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd21786; RBD_KIF20B; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24115:SF534; KINESIN-LIKE PROTEIN KIF20B; 1.
DR PANTHER; PTHR24115; KINESIN-RELATED; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 44..466
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 509..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1102..1151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1320..1466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1541..1582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 605..636
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 811..880
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 909..1000
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1029..1094
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1202..1250
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 511..544
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1332..1380
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1381..1403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1432..1466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 140..147
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1582 AA; 179838 MW; E027A7B424FD738A CRC64;
MESSLNYKPE RVGAVTVEDL RKDLFVEFSK IPTTQDSVLL EREHLQVYLR IRPFTSTESD
FGESQDCISI ESPDTVVLKA PRSSLTARQS EKLGPQIAQR FQFSKVYSPE TTQRQIFDGT
TKALVKDVLA GQNSLIFTYG VTNAGKTFTF LGPETDVGIL PRSLKVIFNS IEGRIYTQNN
IKPHRCIDFT RLTKDQQDAE ATIKKNLLRR YKENDLQKSS SSMSNSACST LLEGSSCSDL
NEDSLCLEED SHVKFSVWVS FCEIYNENIH DLLDFASSSS QRRSVLRLCQ DVKGNTFVKD
LTWIQVNSAD EAYRVLKIGR KNQSFSSTKL NSVSSRSHSI FSIRILRIED MCVPRVQTIS
ELSLCDLAGS ERCAKTQNRG ERLKEAGNIN TSLLTLGKCI NALRLNQTQS KFQQHIPFRE
SKLTHYLQGF FSGRGKACMI VNINQCASMF DETLNVLKFS AVAQKVVVVN PKPVFSAVPR
KSARDVSIMI NNVDKKEWTR RSTLIGWESS LEDVQEDEDD EDMEEGEEDE EEEEQEASDD
ESVMENTVLE AEDDQELNEL QQKICELKEK LSKADSEKLV MESRIREEVT AEFMELFSNM
EKDYNERLQR EKEIAEERAE RRLEILKNLV NKNASELADT SIAGDATEET KNEGLDGMIE
SMQSDLAKIR KDAVAAQTCL EKGAHSPGAV SKLRTQLDQT AKELLKSKQL LEVKTMEIEA
VRVQFRNSSD QLLEANKNYE SQKIRCAELI TICQEKDDDI SKLQTTLDQN IETANEDRAF
IETIKEEILH YRNNCKCILS SGNQDVKDQE IQQLEKALQE KDLCLDELKQ KQHSLEQNLK
DLTDDLAKQT CAHEAAVSLL EAEKAAAVKL ANENRDLASK LCVLQQAASD LSSELRAKQA
ELSSQASVAA KLSEELQTAR ALIREREEEC SDLFDTVESL KLEAENLRQE LSNQGRKSGC
EFQETIEALR KECELVMSNT QEKSKRIKTL EQELTQTKEE MCHMQNQCTQ LKQEQDAQKE
ENQNILGHYE AEKLAVEQMK IRQSELQAEL DDVKQQLAQQ EQHEQAYARS SLRVMELETE
LSEREGHCAA LQERLLHTQD ELGKAKNVLK KERSRSSSEE QEKTNAESSK ARDEAERRRR
EMEEQLVHKD AELEAKTQEL LKSKEQVNDG LDQIKSLTLD LQHKEKHISD LHIQHSEGGA
EAERLRNEIT SLTEEIRKLQ QQLGDLTEER DQALRNLANK KQDIEELKTE QAITASTHEN
LQQYQETCQA LLAKEKLIAE MRLTLSDKER MQTEQEQVLE ARLNEIESLS EELMMLKEKC
QKGGETDSTS GNQRQEEQKG EGTARRLTTD EEELERGLGG ELKPNDAPQR PEEKANHVMD
QSQDKITCKG QLEETAAQDS SVLSTDSERE DKRFPKPQLE ISFTPLKPDR VNVRRPGAEE
SVTVKIRRTA RKRKSAEMEK SVDSENRKNL RLRGNSRVNI QSVESPTVFS KKANRLKQQD
SPASLKGRKD GTLQKIGDFI QSSPTLLGSK AKKIMAMVAV KSPESQIAET NNNKPKRSKR
KLFKTQISSP FDIPSHPVSK DL
//
