ID A0A3B1KIZ4_ASTMX Unreviewed; 590 AA.
AC A0A3B1KIZ4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Solute carrier family 8 member B1 {ECO:0000313|Ensembl:ENSAMXP00000054538.1};
GN Name=SLC8B1 {ECO:0000313|Ensembl:ENSAMXP00000054538.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000054538.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000054538.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3B1KIZ4; -.
DR STRING; 7994.ENSAMXP00000054538; -.
DR Ensembl; ENSAMXT00000051295.1; ENSAMXP00000054538.1; ENSAMXG00000031619.1.
DR GeneTree; ENSGT00940000157433; -.
DR InParanoid; A0A3B1KIZ4; -.
DR OrthoDB; 5482417at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000031619; Expressed in head kidney and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR12266:SF0; MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN; 1.
DR PANTHER; PTHR12266; NA+/CA2+ K+ INDEPENDENT EXCHANGER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..590
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017431390"
FT TRANSMEM 109..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 565..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 113..254
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 432..581
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
SQ SEQUENCE 590 AA; 64980 MW; 5C7ABDD40DABB0AE CRC64;
MKSVFLAAAL VFALRTNHVS SQKWVKLSSA LPVTAENRTT SGDLNLQIPG ASGVLTRDGD
ECDKVMNLSA ADRCEFVLNT PDCAAEGGFI NYPKITFCLL APNLLPLAIF LYIVWLLVMF
LVLGLIASQF FCPNLSAISS TLRLTHNVAG VTFLALGNGA PDVFSAMAAF SRPQTAGLAI
GALFGAGIFV TTVVAGSVTL VKPFTVASRP FLRDIIFYMA AVFWTFTILY KGWIDLKEAL
GYLGLYVLYV ITVVVSTYIY RRRTRSLRGP LQNSEVANDI QASDYYRENI NGTLQEHEAE
YEPLISFTET TSKIFLKSIS PVDTRIWRRS HWAWRALKII QLPFEVVLLL TVPVVDTDKE
DHNWKRPLNC LHIITGPLVC VLTFQSGHYG LYLIQGDFPV WLLTALIGVF LSGIVFCTTN
NERPPPYHFL FSLLGFVVSA LWISTVASEI VSVLHLLGIV LSLSNTVLGL TLLAWGNSIG
DCFSDITIAR QGYPRMAISA CFGGIIFNML FGVGLGCLLQ MFHNGVVMLE PEGLLGWVLS
GALGLSLVLS FVLVPLQRFH LNRAYGIFLL IFYAAFLVVA LLTEFGKIHM
//
