ID A0A3B1KJV2_ASTMX Unreviewed; 701 AA.
AC A0A3B1KJV2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Chloride voltage-gated channel Ka {ECO:0000313|Ensembl:ENSAMXP00000054111.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000054111.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000054111.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3B1KJV2; -.
DR STRING; 7994.ENSAMXP00000054111; -.
DR Ensembl; ENSAMXT00000036670.1; ENSAMXP00000054111.1; ENSAMXG00000012509.2.
DR GeneTree; ENSGT00940000164106; -.
DR InParanoid; A0A3B1KJV2; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000012509; Expressed in head kidney and 2 other cell types or tissues.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd03683; ClC_1_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR PANTHER; PTHR45720:SF3; CHLORIDE CHANNEL PROTEIN CLC-KB; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122};
KW Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 70..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 644..683
FT /note="CBS"
FT /evidence="ECO:0000259|Pfam:PF00571"
SQ SEQUENCE 701 AA; 76698 MW; 009BA48579652576 CRC64;
MEQVYVSYPS LDENKRHGAQ QAGTQSETTQ DKLIISNERP WKPWRSARSR IRGWAIRVQN
AMLCLAGLEW YCYAALGVLM ALMSFVMDLT VAKLLRAHHW LYSCLEGHKL LQFLCWTLYP
ACLCALSTSF SHSICPQSAG SGLPEMRAIL SGVQLPDYLS LSNLFAKLVG LICTLSAGSS
VFLGKVGPFV HLSNMVGAYL HRMYASACGT KQRRTQGDML VVASAVGVAS CFGAPISGVL
FSIEVMGSHY SVRDYCPCFF AAVCGALSYR LLAVCSGEQE TVNALFKTRF PTEIPYQPPE
ILFFALLGLL CGAVSCVYLF SHRWILRFVR ANKLISRFIA TEKTLYSGFV AFLLALVTFP
YSAGSSMASQ LTMRQLICSL LESTQWNSIS HNATLLEESQ QSLWQEWSPP GSSVYKTLGC
FLIIKLWLLV LACTLPLPAG YFMPVFIYGA ALGRFLGEGL AYLFPNGISP DTLSVINPGG
YALVGAAAFA GAVTHTLSPA LCALEMTGQS THVVPILIAT LISNAVSRSK HQPSFYDGIS
LIKKLPHLPS LIRACPKLSS VQIGRFVAPA GAVLQRGEKM AGVQNVLNNS TESQFPVVDT
HESPTLLGTV TRDQLQAFLL EIQTEVLCKS LEDVCHIKPA TLQLSPETTV KQVHCIMSVV
REQRVFVTEN GKLCGLITWK EVRSSAGKHT NTHTHTHKHT S
//
