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Database: UniProt
Entry: A0A3B1KK79_ASTMX
LinkDB: A0A3B1KK79_ASTMX
Original site: A0A3B1KK79_ASTMX 
ID   A0A3B1KK79_ASTMX        Unreviewed;       780 AA.
AC   A0A3B1KK79;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Disintegrin and metalloproteinase domain-containing protein 23-like {ECO:0000313|Ensembl:ENSAMXP00000055003.1};
GN   Name=ADAM23 {ECO:0000313|Ensembl:ENSAMXP00000055003.1};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000055003.1, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000055003.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   AlphaFoldDB; A0A3B1KK79; -.
DR   Ensembl; ENSAMXT00000057075.1; ENSAMXP00000055003.1; ENSAMXG00000007893.2.
DR   GeneTree; ENSGT00940000158781; -.
DR   InParanoid; A0A3B1KK79; -.
DR   OrthoDB; 5406290at2759; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000007893; Expressed in bone element and 11 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR   Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR   Gene3D; 2.10.25.10; Laminin; 1.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR013111; EGF_extracell.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR   PANTHER; PTHR11905:SF13; DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 23; 1.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF07974; EGF_2; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..780
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017210051"
FT   TRANSMEM        744..764
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          250..447
FT                   /note="Peptidase M12B"
FT                   /evidence="ECO:0000259|PROSITE:PS50215"
FT   DOMAIN          453..538
FT                   /note="Disintegrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50214"
FT   DOMAIN          682..719
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DISULFID        510..530
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00068"
FT   DISULFID        709..718
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   780 AA;  86151 MW;  BF9DB84A292049AC CRC64;
     MWLRFLSHLL VSVLVSGLRS SITTALLVEN EPGGDAVSVR VEQDATAPTH TRNESGQEVE
     QAITYPSRLI YFLNENSEST YHNLNTWAKT PGHQGQAVHL AQATFQLEAF GSRFILDLTL
     NNDLLSSDYV EIHYEDGKPI LSKGGEHCYY SGQVRGVEAS RVALSTCNGL HGMFDDGVYV
     YLIEPLKQTH SFEGAARPHT LRRTPSLLQS NDPQDEGDKV EPLLSELDDM SWLRRRKKRA
     IPRNVFEEMK YIELMIVSDH NMFKRHKTKQ QTKNFAKSVV NLVDAVFKEH LNTRVVLVAV
     EIWTDKDQIP ITVYPLEMLR NFSRYRQQHI KQHADAVHLF TNVTFHYHQS SIAFVGGMCS
     VSHGVGVNEY GSTWTMAVSL SQSLAQNLGI RWDVTSKNKE CGCVDSWVGC IMEDTGVQHP
     RKFSKCSISD YKEFLLKGGG SCLFNKPTKL FQTTECGNGY VEVGEECDCG VRAECYKECC
     KKCSLSNGAH CSDGPCCNST CLFYPRGYSC RFAVNDCDIS ETCSGDSGQC PPNLHKQDGH
     LCHLDQGRCY TGECKTRESQ CKYVWGPKSG SSEKFCYEKL NTEGSEKGNC GENGQKWIQC
     SKHDVFCGLL MCTNVGQVPR IGVIKGEITP TTFNHQGNLI ECSGGHVLLD DLTDLGYVED
     GTPCGPSMMC LDRKCLSIQS LNMSACPTGP NGRICSNHGV CNNEATCTCD TTWAGTDCSM
     ADPPKEPPPS EDDGPKVSVA TNRLIGALAG TVLALGVLFG GTGWGREAVK KGRFNENSAI
//
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