ID A0A3B1KLG1_ASTMX Unreviewed; 300 AA.
AC A0A3B1KLG1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Homeobox protein {ECO:0000256|PIRNR:PIRNR000563};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000054910.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000054910.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR000563, ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000256|ARBA:ARBA00006503, ECO:0000256|PIRNR:PIRNR000563}.
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DR RefSeq; XP_007245576.1; XM_007245514.2.
DR AlphaFoldDB; A0A3B1KLG1; -.
DR STRING; 7994.ENSAMXP00000054910; -.
DR Ensembl; ENSAMXT00000047920.1; ENSAMXP00000054910.1; ENSAMXG00000036432.1.
DR GeneID; 103037162; -.
DR CTD; 5308; -.
DR GeneTree; ENSGT00940000154518; -.
DR InParanoid; A0A3B1KLG1; -.
DR OMA; TSHNDIG; -.
DR OrthoDB; 5395268at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000036432; Expressed in camera-type eye and 8 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0061386; P:closure of optic fissure; IEA:Ensembl.
DR GO; GO:0061303; P:cornea development in camera-type eye; IEA:Ensembl.
DR GO; GO:0071907; P:determination of digestive tract left/right asymmetry; IEA:Ensembl.
DR GO; GO:0035462; P:determination of left/right asymmetry in diencephalon; IEA:Ensembl.
DR GO; GO:0060971; P:embryonic heart tube left/right pattern formation; IEA:Ensembl.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0060325; P:face morphogenesis; IEA:Ensembl.
DR GO; GO:0021986; P:habenula development; IEA:Ensembl.
DR GO; GO:0061072; P:iris morphogenesis; IEA:Ensembl.
DR GO; GO:0048382; P:mesendoderm development; IEA:Ensembl.
DR GO; GO:0042476; P:odontogenesis; IEA:Ensembl.
DR GO; GO:0021501; P:prechordal plate formation; IEA:Ensembl.
DR GO; GO:1904103; P:regulation of convergent extension involved in gastrulation; IEA:Ensembl.
DR GO; GO:0043114; P:regulation of vascular permeability; IEA:Ensembl.
DR GO; GO:0048384; P:retinoic acid receptor signaling pathway; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR016233; Homeobox_Pitx/unc30.
DR InterPro; IPR003654; OAR_dom.
DR PANTHER; PTHR45882:SF4; PITUITARY HOMEOBOX 2; 1.
DR PANTHER; PTHR45882; PITUITARY HOMEOBOX HOMOLOG PTX1; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR PIRSF; PIRSF000563; Homeobox_protein_Pitx/Unc30; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|PIRNR:PIRNR000563};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR000563};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR000563};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 74..134
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 263..276
FT /note="OAR"
FT /evidence="ECO:0000259|PROSITE:PS50803"
FT DNA_BIND 76..135
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..74
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 300 AA; 32996 MW; A03F4D5171831604 CRC64;
MNSMKDPLTL EHQQHMAGGK AAALHTPLAM ASSLQPLKPR LEGRSVADSS SPECADKDKS
SSKDDPCDDP CKKKRQRRQR THFTSAQLQE LEATFQRNRY PDMSTREEIA VWTNLTEARV
RVWFKNRRAK WRKRERNQQA ELCKGGFGAQ FNGLVQPYED MYASYPPYNN WAAKSLAPAS
LSAKSFPFFN SVNVSPLSSQ AVFSPPTSIS SMSVSSGMVP TSGLNTPLGN PLNNLGGPSL
NSAPACPYAP PTPPYVYRDT CNSSLASLRL KAKQHSSFSY AGVQTPSNLS ACQYAVDRPV
//
