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Database: UniProt
Entry: A0A3B1KLU8_ASTMX
LinkDB: A0A3B1KLU8_ASTMX
Original site: A0A3B1KLU8_ASTMX 
ID   A0A3B1KLU8_ASTMX        Unreviewed;       529 AA.
AC   A0A3B1KLU8;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Acid-sensing ion channel 1 {ECO:0000313|Ensembl:ENSAMXP00000054909.1};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000054909.1, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000054909.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3B1KLU8; -.
DR   Ensembl; ENSAMXT00000038299.1; ENSAMXP00000054909.1; ENSAMXG00000039218.1.
DR   GeneTree; ENSGT00940000168601; -.
DR   OrthoDB; 3415680at2759; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000039218; Expressed in brain and 3 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.3590.10; acid-sensing ion channel 1 domain; 2.
DR   Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR004724; ENaC_chordates.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00859; ENaC; 1.
DR   PANTHER; PTHR11690:SF252; ACID-SENSING (PROTON-GATED) ION CHANNEL 1C; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        32..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   529 AA;  59713 MW;  C161D4D787D388E7 CRC64;
     MRVSEAGRAF LQCTTLHGAR HIFLSPSPPR RAAWLFAFLA ALALLFTWSS NRVRYLLSAP
     VYTRAHVTHA RRLAFPAVTI CNRNLVRPRS MTKQDVFGLG AWLGLLGRNG KLTAAAREAL
     APPPTGSSAA PARYDPPWLP VSRMLDFEHF LPPPRDAQPS MLQVLDRFGH QLEDMLLQCR
     FQGERCGPRN FSTIFTRYGK CYTFNSGQDG RPLLVTMKGG MGNGLELMLD IQQDEYLPVW
     GETDETSFEA GIKVQIHTQD EPPFIDQLGF GVAPGFQTFV SCQEQRLTYL PPPWGDCRDA
     PMDSDFFTTY SITACRIDCE TRYLVENCNC RMVHMPGDAP YCTPEQYKEC ADPALDFLVE
     RDNDYCVCET PCNMTRYGKE LSFVKIPSKA SAKYLAKKFN KSEQYISDNI LVLDIFFEAL
     NYETIEQKKA YELAGLLGDI GGQMGLFIGA SILTILELFD YLYEVIKYKL CRCAKKSHKR
     SNNNDRGAVL SLDDVKRHTP CENLRTPSTY PANILPHHPG QGNFEDFTC
//
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