ID A0A3B2WCW6_MOUSE Unreviewed; 565 AA.
AC A0A3B2WCW6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Vomeronasal 2, receptor 76 {ECO:0000313|Ensembl:ENSMUSP00000156725.2};
GN Name=Vmn2r76 {ECO:0000313|Ensembl:ENSMUSP00000156725.2,
GN ECO:0000313|MGI:MGI:3761332};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000156725.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000156725.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000156725.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000156725.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000156725.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
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DR AlphaFoldDB; A0A3B2WCW6; -.
DR SMR; A0A3B2WCW6; -.
DR Ensembl; ENSMUST00000233075.2; ENSMUSP00000156725.2; ENSMUSG00000091239.4.
DR AGR; MGI:3761332; -.
DR MGI; MGI:3761332; Vmn2r76.
DR VEuPathDB; HostDB:ENSMUSG00000091239; -.
DR GeneTree; ENSGT00950000183069; -.
DR ChiTaRS; Vmn2r76; mouse.
DR Proteomes; UP000000589; Chromosome 7.
DR ExpressionAtlas; A0A3B2WCW6; differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR CDD; cd06365; PBP1_pheromone_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF409; VOMERONASAL 2, RECEPTOR 76; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..565
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017412881"
FT TRANSMEM 133..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 77..464
FT /note="Receptor ligand binding region"
FT /evidence="ECO:0000259|Pfam:PF01094"
FT DOMAIN 510..549
FT /note="GPCR family 3 nine cysteines"
FT /evidence="ECO:0000259|Pfam:PF07562"
SQ SEQUENCE 565 AA; 65053 MW; 5E2DEF34211FBB10 CRC64;
MFSFISVFLV LKASMLFCSL NEPKCFLRIK DKKNKDGDKE VDCFFSIYTK HGHMKNEHFS
GNLDKQLTTK NIHLILSLYF AIEEINMSPH LLPNISLLVK VECKLLADGS KVSLSSRRGD
YFPNYNCGNH RRYLIVLTGP MWLPTAMLGP LLYISRTPEV RRLYYGPFHP LLSSFEHFPY
LYQIAIKDTS VAIGMVSLVI YFGWNWVGLM ISDDGLGLQF ASELREEMQR YDICLAFVTI
ITYNTKLFLT MTDTYYNQIM MSLAKAVIIF GDKDSLLQVI FRLWQFLDIR RIWVTTSQWD
IITSNGEFLF NSFHGTLSFS HHYSEIAGFK EFIQTAHPLN YSNTISLAKL WWLNFNCFLS
SSNCKSLKTC SRKMLLKWLS RNHFEMSMSD TSYNLYNAVY AVAHSLNELL LQQANTLSNN
VGKGLEFDSL QVLSSLKNIH FVNPAGDLVN LNQKENMNIN YDIFYTGNFL QSFGIKVKIG
KFFKYFTHPQ ELLMYEELVD WATDVRQTLP SICSIPCHPG FRKSPQEGKA VCCFDCIPCP
ENEISNMTAA PVEDTCCLMT STYSR
//
