ID   A0A3B3B4S7_ORYME        Unreviewed;      1862 AA.
AC   A0A3B3B4S7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=SET binding factor 2 {ECO:0000313|Ensembl:ENSOMEP00000000586.1};
GN   Name=SBF2 {ECO:0000313|Ensembl:ENSOMEP00000000586.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000000586.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000000586.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR   Ensembl; ENSOMET00000015615.1; ENSOMEP00000000586.1; ENSOMEG00000001484.1.
DR   GeneTree; ENSGT00940000155385; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   CDD; cd13339; PH-GRAM_MTMR13; 1.
DR   CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR004182; GRAM.
DR   InterPro; IPR037823; MTMR13_PH-GRAM.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR022096; SBF1/SBF2.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR   PANTHER; PTHR10807:SF4; MYOTUBULARIN-RELATED PROTEIN 13; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF02893; GRAM; 1.
DR   Pfam; PF06602; Myotub-related; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF12335; SBF2; 1.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00568; GRAM; 1.
DR   SMART; SM00800; uDENN; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS50211; DENN; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658}.
FT   DOMAIN          12..438
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   DOMAIN          1118..1622
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51339"
FT   DOMAIN          1777..1862
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1090..1113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1673..1700
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1862 AA;  208818 MW;  65F1DBD7F92BF2B9 CRC64;
     MRKAADMARL ADYFVVVGYD QEKSAGSGEG CGKIIQRFPK KDWEGTAFPQ GVEMFCQPGG
     WRLYRERKAP TFFTVVLTDI DSDRHYCSCL TFYEAEVNLQ GSKNIEVDGD EDEEAEEDSL
     IHPAQVFAPK SLILVSRLDY PEIFRGCLGL IYTVYIDSMS FPLEGLVSNL FTFQVPVAGG
     SQKLFSLGAG DRQLIQTPLN NNLPVTHKSV AMLFQQLGIQ NVLSLFCAVL TEHKVLFHSS
     SYQRLGEACR ALEALMFPLK YSYPYIPILP SRLLEVLSSP TPFVIGVHSI FQNEILDLLD
     VIIADLDGGT IKIPECIHLS PLPEPLLHQT QTSLSMVLHP DLEIADNAFP PPRTAPSNLK
     LLDKEVRAVF LRLFAQLFQG YRSCLQLIRI HSEPVIHFHK TAFLGQRGLI ENDFLTKVLD
     GMAFAGFVSE RGPPYRACDL FDGLVALDFD SFREEEVNPS KLQKHIRELS EQMYKNENPN
     PHMAFQKVPR PSEGSHLRVH QVPFPLLDEE KVESMLQEGI AKLSGTPPST RTEKKCVVPA
     GPAVVSIMGK SGSVFNSARR LEVVRSCISF IFENKTLETE KTLPAALRAL KGKAACHCLT
     EELSLHVQQN RAILDHQQFD YVIRMMNCAL QDCSGSEEYT IAAALLPLST AFFRRLAAGV
     NQFAYTCIQD HPVWTNQQFW ECTFYSEVQS QIRSLYLNTP EEKGGASLRI MDEGHVPAAS
     RGEEQTAMDL AAEQLRLWPS LSKEKQQELV KNEESTVFSQ AIHYASLMVY LLVPLDTSKI
     KLLRSTPAAD WESGSNSIVT NSIAGSVAES FDTESGFEDS ENSDVANSVV RFVARFIDKV
     CTESGVTQEH IKSLHSMIPG IVAMQMETLE AVHRESRRLP PIQKPKILRP ALLPGEELVS
     EGLRVMLDPD GREEATGGLL GGPHILPAEG ALFLTTYRII FKGIPHDPLV GEQTVIRAFP
     VSTLTKEKKI SIQNQLQQHM QEGLQLRSAS FQLIKVAFDE EVSSEMVEIF RKHLQRIRYP
     QSVFSSFAFA AGQTTPQLIL PKQKERNTGL KTLSKTIVKG AKRAGKITMG LGSQSSLKKA
     DRSSRMIYHD DDDLSISDDG EPPPSSTLRA SEKSTMEQLV EQSCFRDYQR LGLGTITASS
     SRSKSGEQFR ITAVNRLYSL CRSYPALLVV PQAVQDSSLY KVARCYRHNR LPVLCWKHPR
     TKAVLLRSGG FHGKSVVGLF KSQNPSSTSP ASSSDSSSSL EQEKYLQAIL NSIPVYFKMN
     GNNTLTNRSL IGLSPGSERR TSRMPKMAPV HLEIPFSNSF TRGGMWASLR SSSRLSQHPS
     MAQVGAKLAG KDLAPPAGSS SLQAQLLKHQ AALYIFGEKS HLKGLRVDSS LNCELVPVEF
     ADTRQAKASF KKLLRACAPS STPSDSEDSF LKALEESEWM QQLHKILQLA LFLVELLDSG
     SSVLVSLEDG WDVTTQVVSL VQLLSDPFYR TLEGFQVLLD KEWFSFGHKF CQRSNLSPNS
     QGSGFTPIFL QFLDCVHQIL EQYPLEFEFN QYYLKFLAYH HISNRFKNFL LDSEYERLEH
     GLLFDDKGDK QTRKGICIWD CINRMHRRSP IFFNFLYLPS DSDAVLKPFV AVSSLRKWDF
     FTDETLSTGP CYDWKMMAVR SDGSAEADAI ANSKRRIVWP CYSSVSHAQP DAITKLLADI
     EKLEGELNQT QEKWQTTLER VRISIQEDLK QEENLRKQSA SISGLIPTPN IQPFHRRSMM
     HLPESGLADD HTSSTANGVN RRAATLYNQF TPKSEENRSY EGILYKRGAL LKGWKPRWFV
     LDVTKHQMRY YDTGEDTNCR GHIDLAEVES AMIATPSLGA PKHISEKAFF DVSMIYLDLL
     RK
//