ID   A0A3B3B6Z5_ORYME        Unreviewed;       782 AA.
AC   A0A3B3B6Z5;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Eosinophil peroxidase-like {ECO:0000313|Ensembl:ENSOMEP00000000932.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000000932.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000000932.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B3B6Z5; -.
DR   STRING; 30732.ENSOMEP00000000932; -.
DR   PaxDb; 30732-ENSOMEP00000000932; -.
DR   Ensembl; ENSOMET00000015049.1; ENSOMEP00000000932.1; ENSOMEG00000001821.1.
DR   GeneTree; ENSGT00940000156009; -.
DR   OrthoDB; 4560at2759; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR   InterPro; IPR019791; Haem_peroxidase_animal.
DR   InterPro; IPR010255; Haem_peroxidase_sf.
DR   InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR   PANTHER; PTHR11475:SF63; EOSINOPHIL PEROXIDASE; 1.
DR   PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR   Pfam; PF03098; An_peroxidase; 1.
DR   PRINTS; PR00457; ANPEROXIDASE.
DR   SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR   PROSITE; PS50292; PEROXIDASE_3; 1.
PE   4: Predicted;
KW   Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..782
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017275260"
FT   BINDING         489
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ   SEQUENCE   782 AA;  88766 MW;  440AEDF725039C24 CRC64;
     MLLSVLFVLG ISLVPAHFKP TGETLGSPFL QQCFEDAKKL VDDAYKYSRE ESLRRVRKEV
     VRPHDALRLL KQPRGDTRSA VRSADYMAQT LRLVHDRVHN VHKRSLNATD LLTGDDMLKL
     AEISGCAARV RLPQCLTVPN LNKYRTATSV CNNLNNPRLG ASNTPFTRWL PAEYDDGISQ
     PKGWNRNRTF NNFMLPLVRQ VSNNILSMTD AGVVNDDEFT HMVTLFGQWN DHDLSFTPVS
     PSIRSFSNGL NCDESCEQSE PCIPIPIPPG DPRLPSRPDS CIPAFRSAPV CGTGYSAYNF
     GGEPNKREQI NALTAFLDLG QVYGSEEKLA LYLRNLSSDA GLMRVNTEFR DKGRELLPFH
     PMQVQMCATR RKITNNPNAQ EVPCFIAGDV RVDENIALTS IHTLFLREHN RLARQLKRLN
     PHWDSETLYQ EARKIMGAYT QKLVFKDYLP HIVGDEAMKK QLDQYPGYNS EIDPSIANVF
     ATAAYRFAHL AIQPSLSRLD ENYREHPQFP SVPLYEAFFT PWRVVFEGGI DPVLRGLLGQ
     PAKLNTQDQM MVDALRERLF QFVQRLALDL GSLNMQRSRD HGIPGYNAWR KFCGLSQPRN
     VAELSQVLGN EDLARRLLQL YGTADNIDVW LGGVAEPFVR GGRVGPLFAC LIATQFQKIR
     QGDRLWYENP GVFTRFQRNA LRSVRLSKII CDNTDITSVP VNVFKVVSRQ NRRVLCSRLS
     GINMSPWRDR SCVGENCFGN TFQEDLYKED LNNIDLDELD QIDPEVDQDL EVDPENLNNE
     IQ
//