ID A0A3B3B711_ORYME Unreviewed; 1267 AA.
AC A0A3B3B711;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRT {ECO:0000313|Ensembl:ENSOMEP00000000828.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000000828.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000000828.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR AlphaFoldDB; A0A3B3B711; -.
DR Ensembl; ENSOMET00000015218.1; ENSOMEP00000000828.1; ENSOMEG00000001773.1.
DR GeneTree; ENSGT00940000155326; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd06263; MAM; 1.
DR CDD; cd14630; R-PTPc-T-1; 1.
DR CDD; cd14634; R-PTPc-T-2; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF8; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 1..128
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 130..221
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 228..321
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 322..427
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 715..969
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 889..960
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1001..1263
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1177..1254
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 615..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1267 AA; 141866 MW; 25985031A0065310 CRC64;
LFSICVCAGS YMVVNASGRA SWQKAHLYMP VLKENDTHCI DFLYSLSSRD GASPGTLNVY
IKVNGGPQGN PVWNASDTVT EGWVKAELAI STFWPNSYQV IFEAVSVQGH PGYIAIDDIR
VLAHPCRKAP HFLRLQNVEV NVGQNATFQC TAGGKWSQQD KLWLQQWNGK DTALMVTRVV
NHRRFSATVS VGDTSQRSTS RYRCVIRSDG GSGVSNYADL IVKAPPTPIA PPELLAVGAT
YLWIKPNANS IIGDGPIILK EVEYRTTTGN WAETHVVDSP TYKLWHLDPD VEYEIKVLLS
RPGEGGTGPP GPPLVTRTKC AVPGSVPMES LQNTPYEEKI FMQWKAPNET NGAITLYEIT
YKALSSLDPS ADLTTQRGRV FKLRNETHHM FVGLYPGTTY FFTLKASTNK GFGPPVTNRI
STKIAAPMMP EYDSESPLNE TETTITILLK PAQSRGAPIS SYQLVVKEER KSKTRRAAPE
ALECFSAPVS FRNASILDSP YYIAADLPPS SLTVVQPFTV GDNKSYGGFW NPPLSPAKSY
SIYYQAMSRA NGETKINCVR LAHKGASTQD SDAMEPEKQV DSTVKMAGVI AGILMFIIIL
LGLVLTFKRR KLAKKQKETA SSSTQQREMG PVTTADKSTT KVSTLHKDDP FSTSNQDLNG
FNSSQPSLSQ PSLTLQSFPY GGCESFQAGQ FQPAIRVADL LQHITQMKCG QGYGFKEEYE
ALAEGQTAPW ETAKKDENRN KNRYGNIIAY DHTRVRLQLL DGDPHSDYIN ANYIDGYHRP
RHYIATQGPM QETVRDFWRM VWQENTASIV MVTNLVEVGR VKCVRYWPDE TEVYGDIKVT
LIETEPLAEY VIRTFTVQKK GHHEIRELRQ FHFTSWPDHG VPCYATGLLG FIRQVKFLNP
PDAGPIVAHC SAGAGRTGCY IAVDIMLDMA ENEGVVDIFN CIRELRSQRV NMVQTEEQYV
FVHDAILEAC LCGNTAIPVC DFRAIYYNIS RIDPQTNSSQ IKDEFQTLNI VTPRVRPEDC
SVGLLPRNHD KNRSMDVLPA DRCLPFLISV DGESSNYINA ALMDSHKQPA AFIVTQHPLP
NTISDFWRLV FDYNCSSIVM LNEMDAAQLC MQYWPEKNSC CYGPIQVEFI SADIDEDIIN
RIFRICNMAR PQDGYRLVQH FQFIGWPAYR DTPLSKRSIL QLVRRLAKWQ EQYDGGDGRT
VVHCLTGGGR SGTFCAICSI NEMIQQQNIV DVFHTVKTLR NNKTNMVETM EQYKFCYEVA
LEALNSF
//
