ID   A0A3B3B811_ORYME        Unreviewed;       789 AA.
AC   A0A3B3B811;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000001173.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000001173.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   AlphaFoldDB; A0A3B3B811; -.
DR   Ensembl; ENSOMET00000014632.1; ENSOMEP00000001173.1; ENSOMEG00000002077.1.
DR   GeneTree; ENSGT00950000182881; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF22; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 2; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        349..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        394..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        488..506
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        518..541
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        584..607
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        719..742
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          41..68
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   789 AA;  90792 MW;  6BCE1430BB458484 CRC64;
     MERILGYLLR EIKKADISLP ERDVNPVTPS PKNVISIMEQ LQRFEAELGE VTRNKERLQK
     NLLELTEYTH MLRISRNFVQ RPIEREPHQV QYEEFPFLEK DTVMDYSSMQ RLGAKLGFIS
     GLIQRAKIEA FERMLWRVCK GYTILSYAEV EEYLQDPDKG EPVKCVVFLI SYWGDQIGQK
     VKKICDCYHC HLYPYPNSNE ERNDVVEGLK TRIQDLHTVL HRTEDYLKQV LVKASESVYT
     WVVQVKKMKA IYYILNLCSF DVTNKCLIAE VWCPVSDIPT LRRALEDGSK KSGSTVSSFV
     NRIPTTDTPP TLIRTNKFTS GFQNIVDAYG VGTYREVNPA PFTVITFPFL FAVMFGDLGH
     GVIMALFALW MVFYENNRKL KNTRNEIWNT FFEGRYIILM MGIFSIYTGL IYNDCFSKSL
     NIFGSGWSVS AMFKTGVWTK DVLHGNRFLT LDPNVTGVFT GPYPLGIDPI WNLASNRLTF
     LNSYKMKMSV IVGVIHMSFG VILSTFNHTY FKKKYNLYLV FLPELLFLLC LFGYLVFMIF
     YKWLAFSAID SRHAPSILIH FINMFLMQGE EVQPLYPGQH GLQVFLVVIA VLSVPVLLLG
     KPLYLYWLQH GRQHLGMYRG YERVRRSSEE ELYLLRTHDE EEGSSYSDLS GSGEQSSEEF
     NLADEFLHQA IHTIEYCLGC ISNTASYLRL WALSLAHAQL SEVLWAMVMR VGLRMDTSLG
     VLFLVPVFGL FAVLTVSILL VMEGLSAFLH ALRLHWVEFQ NKFYSGTGVK FCPFTFSALP
     SSFESDGLL
//