ID   A0A3B3B857_ORYME        Unreviewed;       806 AA.
AC   A0A3B3B857;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Follistatin like 5 {ECO:0000313|Ensembl:ENSOMEP00000001761.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000001761.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000001761.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR   AlphaFoldDB; A0A3B3B857; -.
DR   Ensembl; ENSOMET00000013635.1; ENSOMEP00000001761.1; ENSOMEG00000002696.1.
DR   GeneTree; ENSGT00940000156495; -.
DR   OMA; THSYDIY; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0071840; P:cellular component organization or biogenesis; IEA:UniProt.
DR   CDD; cd00096; Ig; 1.
DR   CDD; cd05736; IgI_2_Follistatin_like; 1.
DR   CDD; cd00104; KAZAL_FS; 1.
DR   Gene3D; 3.30.60.30; -; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR10913; FOLLISTATIN-RELATED; 1.
DR   PANTHER; PTHR10913:SF44; FOLLISTATIN-RELATED PROTEIN 5; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF13927; Ig_3; 2.
DR   Pfam; PF07648; Kazal_2; 1.
DR   SMART; SM00054; EFh; 1.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 2.
DR   SMART; SM00280; KAZAL; 1.
DR   SUPFAM; SSF75011; 3-carboxy-cis,cis-mucoante lactonizing enzyme; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50835; IG_LIKE; 2.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Membrane {ECO:0000256|ARBA:ARBA00022989};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          40..94
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51465"
FT   DOMAIN          134..169
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          209..282
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          300..385
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   806 AA;  90765 MW;  953179979DA37213 CRC64;
     LCIYSIVFIS SPGFLGHGGH PGPCEHKYCG LGRHCVVNHE TKQGECKCLD HSKPHYKPVC
     GSDGKLYQNH CELHRASCLR GHKITIMHSE ECYYKDDACR LSDYHRLKTK ILDLQDRRFT
     GSAFRGAHHD TMAAKKQLVD VMFKSFDIDN DGRIDASELS QVIKHEGLSM DATDCTLFDL
     LKYNDVNDDE HLTKEEFYTA FDVYLLSLPD DQKVTVTTMT AGESAVLTCA ITGERRPPIL
     WKRNHQYLNS LNLEDINDFG DDGSLYITKV TTTHMGNYSC HADGYEKLFQ THILQVNVPP
     VIRVYPESQA REPGITASLR CHAEGIPSPQ LSWLKNGMDI KVKLSKQLTL QANGSEVHIS
     NVHFEDTGAY TCIAKNEAGV DEDISSLFVE DSARKTLANI LWREEGLGIG NMFYVFYDDG
     IKVIQPVACE IQRHIKPSEK LLALQEEVCP MSPGETVQKC VWSSAVNIKD KFIYVTQPTL
     DRVLVVDIQS QKAVQTVSTD PYPVKLHYDK SHDQVWLLSW GDMEKNFPTL QVINQASGRV
     SHHTVHTQPV GRRFDRVEDF FIPASSLIAN HVRFGLILHK NEPVLHKINL ETTSYVKNIS
     LWEYNCIPSS VAYTHLGGYY FINCKADSTG ATQPQVILDS VTDSVIGQNR DITGTPYVSP
     DGRYLVTVDD GDGLMRIQRV SERGEIQEPF DIHTNLHLSD LAFQRSFTEV HQYNVFGSSG
     RQTDVLFVEL SSGKVKMIKS LKEATKSFDW PWSNKNRVVV GSGLFGQYLV TPSRESVFIL
     DGRLNKLNCE IMDVLKGNVV VWVGDS
//