ID A0A3B3B8F8_ORYME Unreviewed; 1841 AA.
AC A0A3B3B8F8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 {ECO:0000313|Ensembl:ENSOMEP00000001424.1};
GN Name=TANC1 {ECO:0000313|Ensembl:ENSOMEP00000001424.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000001424.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000001424.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TANC family.
CC {ECO:0000256|ARBA:ARBA00038259}.
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DR Ensembl; ENSOMET00000014202.1; ENSOMEP00000001424.1; ENSOMEG00000000038.1.
DR GeneTree; ENSGT00940000155655; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR24166:SF23; PROTEIN TANC1; 1.
DR PANTHER; PTHR24166; ROLLING PEBBLES, ISOFORM B; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 10.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 913..945
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1024..1056
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1057..1089
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1090..1122
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1123..1155
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1156..1188
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1282..1315
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1368..1410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1453..1487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1520..1540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1570..1634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1651..1691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1703..1728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1389..1410
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1526..1540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1579..1618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1841 AA; 200752 MW; 43125103C08C8E28 CRC64;
MFKAVLKKNR DGGRGSKKDS GPIRKPKYVE SPRVPSDALG SSLRKVSDKK SSHNDLQAEQ
QPSSSSPATQ ELMTRLGFLL GEGIPGTAHI PMDDKNEKKS SLTCQGISPC STLTSSTASP
STDSPCSTLN STTSRPPLSR SSPCGTITSP SSTLESKDSG IIATITSSSE NDDRSGSSLE
WSKDGSLRGN GRHGLAQCVR ADTCSPVVEE DSSSAAGADH QLQKMSTGLT GPTQAQSHTP
EGSGPYLPQT TSSLMMPRPN SVAATSSTKL EDLSYLDEQR NTPLRTSIRL PWHNTGGRPP
HDSKARFSPY KPADIMLKPL LFEVPSITTD SVFVGRDWLF QQLEDVLKAT ESNGNQGAVI
LGSVGHGKTA VISRLVALSC HGGRMRQIAS NSPSASPKAQ STELLLSQPA QATPPSSAAN
TLRTSNCPGT PEVQRRREEP VKRLASKVVA YHYCQADNTY TCLVPEFVHS IAALLCRAHQ
LGAYRELLLK EPHLQSMLSL RSCVQDPMAA FRRGILEPLV NLRKERRISE EDHIILIDGL
NEAEFHKPDY GDTIASFIAK IITKFPSWLK LVVTVRANLL EITSLLPFAK ISLDEFSDNK
EIPNDLNAYI QYRINGSKDI MNNISLNGKA DSASVSRLSS HLISRSQGSY LYLKLTLDLF
ERGHLVIKSA SYKVVPVSLT ELYQLQCNMK FMTNSAFERT LPILNVALAS LHPLTDEQLF
QAINAGSVRG ELQWEDFQQR LDLLSSFLIK RRDKTRMFCH PSFREWLVWR ADGESTDFLC
DPRTGHAFMA FMLSRQEGKL NRQQTMELGH HILKAHIFKG LSKKTGVSSS VLQALWISCS
TDGLSAALAS LRNLYTPNVK VSRLLMLGGA NVNYRTEVLN NAPILCIQCH LGHLEMASLL
LEFGASLDVV SENGMSPLCF SAAAGHTGLV MLLCKRGAKV DHVDKSGQCA LVHAALRGHT
EIIQYLLELE WIAEGLQQDC SLKNKALQQA LIAASSMGHT QVVRSLLVLK NEHAVQIDSH
DTLWGETALT AAAGRGKMEV CSFLLDQGAL VQQVNRRGVS SLFCAVRQGH WQIAELLLQH
GADINISDKQ GRTLLMVAAC EGHLSTVEFL LSKGASLTQM DKEGLMPLSW ACLKGHKDVV
QFLVEKGAII DHTDKNGRTP LDLAAFYGDA EIVQYLVEKG AVIEHVDHSG MRPLDRAIGC
RNTSVVVTLL KKGAKLGNAS WAMATSKPDI LIILLQKLME EGNLLYKKGK MKDAAQRYQY
ALRKFPREGF GDDLKPFKDL RVSLYLSLSR CRRKTNDFGM AEEFATKALE LKPKSYEAYY
ARARAKRSSR QFTAALADLH EAAKLCPNNR EIRRLLARVE DECKQMQRSQ AKGGVAGAAA
ACSQASRGQE SDPEHEDGQE EPSEHSLARS VEAQREILEE EEEDDEEEEG VSLKHDRTGE
ACWTHNNYSF NRVLPSDPPA ASSCPGHQNQ TPSSPPGPGR LPPHRYPREH REPLAQQALV
MQPTKQAQIV KTNQHMGAVG GRSTGAKSQY APSSPLPSRH MSSMLKPGPG IDISPLPTPA
EEPVYGNRAL PAAASPCDND NLLSPQTSYN GSKALGQDRL SVHSASSLDG SAISGHTGNH
SDPGKEGMCP AAAASQGGSL SCMRVSSSTS SLASSSSLSD SGKLGPDVRS KISDKPKLSQ
QAGSAAEYKP RPFMGITDKT ARFQQQQQVQ QHHHSLQSHP SLQSTGRSWL SRSCDGPVCQ
NMSAVSLQPA DCEFPYSRAG GVYQEQHKHP PVQSAMTLSG LQNGMHAKEF AEKFCQAANC
FKESKPPLAV PHPKQHGLAR DNPAIHVASM KPKRSFIESN V
//
