ID   A0A3B3B8V6_ORYME        Unreviewed;       764 AA.
AC   A0A3B3B8V6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
DE            EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000001980.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000001980.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|PIRNR:PIRNR001251};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC       ECO:0000256|PIRNR:PIRNR001251}.
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DR   AlphaFoldDB; A0A3B3B8V6; -.
DR   Ensembl; ENSOMET00000013269.1; ENSOMEP00000001980.1; ENSOMEG00000002921.1.
DR   GeneTree; ENSGT00950000183011; -.
DR   OMA; MICECLD; -.
DR   UniPathway; UPA00591; UER00663.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR   CDD; cd01319; AMPD; 1.
DR   Gene3D; 4.10.800.20; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR006329; AMPD.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01429; AMP_deaminase; 1.
DR   PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR   PANTHER; PTHR11359:SF2; AMP DEAMINASE 3; 1.
DR   Pfam; PF19326; AMP_deaminase; 1.
DR   PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR001251};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR001251}.
SQ   SEQUENCE   764 AA;  89042 MW;  60D464DC0073E095 CRC64;
     MAQVTTEDVP RIFQRLSMNE IEESVRLMAE KVYASAIREE DNKGALALFT VPEDCPIGLL
     EDRERALQKE LAEQQSQESI KRRKNFLLKR SQSVSLQIPE SFDRTPSEVS PIPTPVEIES
     CPPVSFPEYQ RVTISGDYCA GITVDDYEQA TKSLLHALIA REKYSKLAYH RFPRTTALFL
     RTAQNEKWQE EDEVLPDIKP FPQDEDVYSM ENIPENTNYV LQLKDGIVHV YENEEALKNN
     QPHKLPYPDL ETFAIDLSYV LAMIADGPTK TYCHRRLNFL ESKFYLHEML NEMAELKELK
     CVPHRDFYNV RKVDTHIHAA ACMNQKHLLK FIKQTYHTEA DRIVMEKGSQ KFTLKQVFKN
     LNMDPYDLTV DSLDVHAGRQ TFHRFDKFNS KYNPVGASEL REIYLKTDNH INGEYFARLI
     KEVAKDLEES KYQHAEPRLS IYGRSPSEWE SLATWFIQHK VHSPNMRWMI QVPRIYDIFR
     SKKLIPNFAK MLENIFLPLF EATVNPQKHK TLHVFLQYVT GFDSVDDESK HSDHLFSYKS
     PTPEDWTQDD NPPYTYYLFY MYANIMVLNN LRREREMNTF MFRPHCGEAG SITHLVSAFL
     TADNISHGLN LKKSPVLQYL YYLAQVPIAM SPLSNNSLFL QYSKNPLREF LHKGLCVSLS
     TDDPMQFHYT KEPLMEEYAI AAQLWKLSTC DLCEIARNSV LQSGLSHQEK KHFLGSNYLQ
     DGPEGNDIRR TNVAQIRMTY RYETLRNELS FLVDAVKTEE AQQA
//