ID   A0A3B3BB10_ORYME        Unreviewed;       585 AA.
AC   A0A3B3BB10;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=SH2 domain-containing protein {ECO:0000259|PROSITE:PS50001};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000002349.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000002349.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC       {ECO:0000256|ARBA:ARBA00009442}.
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DR   AlphaFoldDB; A0A3B3BB10; -.
DR   STRING; 30732.ENSOMEP00000002349; -.
DR   PaxDb; 30732-ENSOMEP00000002349; -.
DR   Ensembl; ENSOMET00000012633.1; ENSOMEP00000002349.1; ENSOMEG00000003403.1.
DR   GeneTree; ENSGT00940000157050; -.
DR   Proteomes; UP000261560; Unplaced.
DR   CDD; cd09930; SH2_cSH2_p85_like; 1.
DR   CDD; cd09942; SH2_nSH2_p85_like; 1.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 2.
DR   InterPro; IPR032498; PI3K_P85_iSH2.
DR   InterPro; IPR035020; PI3kinase_P85_cSH2.
DR   InterPro; IPR035022; PI3kinase_P85_nSH2.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR   Pfam; PF16454; PI3K_P85_iSH2; 1.
DR   Pfam; PF00017; SH2; 2.
DR   PRINTS; PR00678; PI3KINASEP85.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 2.
DR   SUPFAM; SSF55550; SH2 domain; 2.
DR   PROSITE; PS50001; SH2; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}.
FT   DOMAIN          193..288
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          481..576
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   REGION          97..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          302..343
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          395..422
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   585 AA;  67616 MW;  75E80966EB33E7C4 CRC64;
     MMCFKQAWRT GSTSPTLSDS PRHKTKQDCT VSVVKMAAKS FHLWTEEELK PSDVPTSSLA
     SLQLTDEAVV MSENTVHMVD NPKPDPIFPE MTSPLLHQSR QQSDISIATK PEPPPADQES
     LEKEKGHSSS EVQSCTPRVF LQDLSSHTDE DDEAVLALKT SSKEKVWSES DTTKSMAAYD
     SNADNLQLSE AEWYWGSISR EEVNDLMRNT PDGTFLVRDS SSRNKGEYTL TLRKDGYNRL
     IKIFQYGEKC GFSEPLVFPS VVDLIQYYQK KSLAQYNSKL DTRLLYPISR FQEQHLVMEV
     DIDAAGEQLR IYQDQYKETS KEYDQLFKEL NQTSQELQSK RTAIEAFTEI IRIFEEECET
     QERYSKEYID MFLALDNSTN TEKIQSNPEE LQSRVEEIHS SKKKLEEELK KKALAHMEVD
     RKMNGLKPDL VQLRKIRDQY LLWLTQQGTS QSQINEWLGI KREEEDLYTL EDDTHQEERS
     WYVGGMRRKE AEELLRGRRD GTFLIRESQT QRGSFACSVV VDGEVKHCVI YRTATGYGFA
     EPYNLYSSLR ELVLHYRHTS LIQHNQQLNV TLAWPALSQP FSEET
//