ID A0A3B3BB65_ORYME Unreviewed; 572 AA.
AC A0A3B3BB65;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Frizzled class receptor 8 {ECO:0000313|Ensembl:ENSOMEP00000002278.1};
GN Name=FZD8 {ECO:0000313|Ensembl:ENSOMEP00000002278.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000002278.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000002278.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
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DR AlphaFoldDB; A0A3B3BB65; -.
DR STRING; 30732.ENSOMEP00000002278; -.
DR PaxDb; 30732-ENSOMEP00000002278; -.
DR Ensembl; ENSOMET00000012752.1; ENSOMEP00000002278.1; ENSOMEG00000003212.1.
DR GeneTree; ENSGT00940000161191; -.
DR OMA; MDRFKYP; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd15250; 7tmF_FZD8; 1.
DR CDD; cd07461; CRD_FZ8; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR041776; FZ8_CRD.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF146; FRIZZLED 8A PROTEIN-RELATED; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 233..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..137
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 231..524
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 148..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 21..82
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 29..75
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 66..104
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 93..134
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 97..121
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 572 AA; 64188 MW; 88EF9AFA285B5735 CRC64;
MSFSALILHG TRCLAAKELQ CQEISVPLCK GIGYNYTHMP NKFHHDTQDE AGLEVHQFWP
LVEIKCSPDL RFFLCSMYTP ICLEDYKKPL PPCRSVCERA KAGCAPLMRQ YGFPWPDRMK
CDLLPEQGNQ DTLCMDYNRS QTTTVSPALA KPTNRPLKPY NKRKGPYGRT VPGKHKPAAS
PCEAGCSCRA PMVPVTSDPH PLHNRVQTGQ ILNCAMPCHN PYFTQEERTF TSFWIGLWSI
LCFISTFTTV ATFLIDMERF KYPERPIIFL SACYMFVSVG YIVRLIAGHE EVACNAGNGA
GHIHYETTGP ALCTVVFLLI YFFGMASSIW WVILSLTWFL AAGMKWGNEA IASYSQYFHL
AAWLIPSMKS IAVLALSSVD GDSVAGVCYV GNQNLDNLRG FVLAPLVIYL FIGTMFLLAG
FVSLFRIRSV IKQGGTKTDK LERLMIRIGV FTVLYTVPAT VIVACYFYEQ HNRQAWEITH
NCTCATEPSR QRPNYAVFML KYFMCLLVGI TSGAWIWSGK TLDTWRTFCT RCCWGSKASA
SSMYSDVSTG LTWRSGTASS VSCPKQMPLS RV
//
