ID A0A3B3BCL9_ORYME Unreviewed; 377 AA.
AC A0A3B3BCL9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Paired box protein Pax-8 {ECO:0000256|ARBA:ARBA00039822};
GN Name=PAX8 {ECO:0000313|Ensembl:ENSOMEP00000002947.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000002947.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000002947.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3B3BCL9; -.
DR Ensembl; ENSOMET00000011650.1; ENSOMEP00000002947.1; ENSOMEG00000003907.1.
DR GeneTree; ENSGT00940000161868; -.
DR OMA; CNISCYA; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00131; PAX; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR022130; Pax2_C.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45636; PAIRED BOX PROTEIN PAX-6-RELATED-RELATED; 1.
DR PANTHER; PTHR45636:SF6; PAIRED BOX PROTEIN PAX-8; 1.
DR Pfam; PF00292; PAX; 1.
DR Pfam; PF12403; Pax2_C; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 4: Predicted;
KW Paired box {ECO:0000256|ARBA:ARBA00022724};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 8..134
FT /note="Paired"
FT /evidence="ECO:0000259|PROSITE:PS51057"
FT REGION 142..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 377 AA; 40692 MW; BDA1CAE23ED31E06 CRC64;
IPQSSFNSHG GLNQLGGMFV NGRPLPEVIR QRIVDMAHQG VRPCDISRQL RVSHGCVSKI
LGRYYETGSI KPGVIGGSKP KVATPKVVEK IAEYKRQNPT MFAWEIRDRL LAEGVCDSDT
VPSVSSINRI IRTKVQQPFN LPLDGKGLSP GHTLIPSSAV TPPESPQSDS VGSTYSINGL
LGIAQPNSDG KRSHDDSDQE SCRHSVDSQG SGSVPRKQMR LDQFSTHLDC GFDRHHYPPE
SFSSSSSNKT EQTLYPLSLV NGSLDEAKTT LSSTSVIGRN LSAHQSYTMV TGRDMMSSTL
PGYPPHIPSP AQSGYSSSAI TGMVAGADYS GQSYSHSPYT SYSEAWRFTN SSILGSPYYY
SSASRTGPPS AAAYDHL
//
