ID   A0A3B3BCM0_ORYME        Unreviewed;       819 AA.
AC   A0A3B3BCM0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Neuroligin-3 {ECO:0000313|EMBL:KAF6728890.1, ECO:0000313|Ensembl:ENSOMEP00000002909.1};
GN   ORFNames=FQA47_000441 {ECO:0000313|EMBL:KAF6728890.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000002909.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000002909.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:KAF6728890.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bigg-433 {ECO:0000313|EMBL:KAF6728890.1};
RX   PubMed=32938378;
RA   Liang P., Saqib H.S.A., Ni X., Shen Y.;
RT   "Long-read sequencing and de novo genome assembly of marine medaka (Oryzias
RT   melastigma).";
RL   BMC Genomics 21:0-0(0).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000256|ARBA:ARBA00005964}.
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DR   EMBL; WKFB01000269; KAF6728890.1; -; Genomic_DNA.
DR   STRING; 30732.ENSOMEP00000002917; -.
DR   PaxDb; 30732-ENSOMEP00000002917; -.
DR   Ensembl; ENSOMET00000011699.1; ENSOMEP00000002917.1; ENSOMEG00000003856.1.
DR   Ensembl; ENSOMET00000011712.1; ENSOMEP00000002909.1; ENSOMEG00000003856.1.
DR   GeneTree; ENSGT00940000167278; -.
DR   OMA; WSKYDPF; -.
DR   OrthoDB; 4386at2759; -.
DR   Proteomes; UP000261560; Unplaced.
DR   Proteomes; UP000646548; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042043; F:neurexin family protein binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007416; P:synapse assembly; IEA:UniProt.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019819; Carboxylesterase_B_CS.
DR   InterPro; IPR000460; Nlgn.
DR   PANTHER; PTHR43903; NEUROLIGIN; 1.
DR   PANTHER; PTHR43903:SF27; NEUROLIGIN 3B ISOFORM X1; 1.
DR   Pfam; PF00135; COesterase; 1.
DR   PRINTS; PR01090; NEUROLIGIN.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000646548};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        684..707
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          50..612
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
FT   REGION          633..675
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          710..774
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        633..658
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        717..751
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        759..774
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   819 AA;  91314 MW;  94CF05E756C27AD2 CRC64;
     MWLATFRGHL LPTHLLHQQG TTTIAHCALL WWISCSCWSL TKATSQKFYP TVTTQFGKLR
     GLRVPVPSEV LRPVDQYLGV PYAAPPVGEK RFMPPEQPSS WSGVKNATHF MPVCPQNIHS
     TVPEIMMPIW FTYNLDTVAT YIQDQSEDCL YLNIYAPTDD GSQHRKKGAS FSHAEIHISE
     DIRDSEARPV MVYIHGGSYM EGTGNMMDGS ILASYGNVIV VTLNYRIGIL GFLSTGDQAA
     KGNYGLLDQI QALRWISKNI GYFGGDPGRI TVFGSGIGAS CVSLLTLSHH SEGLFHRAII
     QSGSALSSWA VNYQPVKYTR MLAERVGCNV LDTVDMVSCL QKKTAKELVE QDIQAARYRV
     AFGPVIDGDV IPDDPEILME QGEFLNYDIM LGVNQGEGLR FVENAMDLED GVSGSDFDFA
     VSDFVDSLYG YPEGKDTLRE TIKFMYTDWA DKDNPETRRK TLVALFTDHQ WVEPSVVTAD
     LHARYGSPTY FYAFYHHCQS LMKPVWSDSA HGDEVPYVFG IPMVGPTDLF PCNFSRNDIM
     LSAVVMTYWT NFAKSGDPNK PVPQDTKFIH TKANRFEEVA WSKYNPYDQM YLHIGLKPRI
     RDHYRATKVA FWKHLVPHLY NLHDMFHYSS TTTKVTPLDP TQSNGKRSGS TGRPPISTAN
     SHGEGGGEMG PLIMPNPRDY STELSVTIAV GASLLFLNVL AFAALYYRKD KRSRQETSQQ
     PSPQRESKGN SAGHTNTVDE TLSSQQRNPC EALHNPLHVS PSYSISQRRS PDDIPLMTPN
     NITMIPNSLM GLSNMSPYST FPAGYSSAGL PSTHSTTRV
//