ID   A0A3B3BD73_ORYME        Unreviewed;       484 AA.
AC   A0A3B3BD73;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Thiamine transporter 1-like {ECO:0000313|Ensembl:ENSOMEP00000002983.1};
GN   Name=SLC19A3 {ECO:0000313|Ensembl:ENSOMEP00000002983.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000002983.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000002983.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC
CC       2.A.48) family. {ECO:0000256|ARBA:ARBA00005773}.
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DR   AlphaFoldDB; A0A3B3BD73; -.
DR   Ensembl; ENSOMET00000011608.1; ENSOMEP00000002983.1; ENSOMEG00000000089.1.
DR   GeneTree; ENSGT00950000183022; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR002666; Folate_carrier.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   NCBIfam; TIGR00806; rfc; 1.
DR   PANTHER; PTHR10686; FOLATE TRANSPORTER; 1.
DR   PANTHER; PTHR10686:SF35; THIAMINE TRANSPORTER 2; 1.
DR   Pfam; PF01770; Folate_carrier; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        71..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        96..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        126..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        187..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          215..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..256
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   484 AA;  54621 MW;  CAA34E6A254793BC CRC64;
     MGGSRAHVIT SDRWTNMEAV KRWRSSWRFP TTLLCIYGFF STVKPLEPFL IPFLTGPDKN
     LTTEQVNGQI FPVWTYSYLS VLVPVFLLTD WLRYKPVLMF QSAVLFITTA LLRWADGVAA
     MQAMQFFYGV VTASDVAYFS YIYSVVDLKR YRKATSYSRS VQLLGYTVGS ILGQVLVSFD
     LMSYNHILVF TMVLTASALV TSCFLPMPEQ SMFFHPNPST KRGDADSNTS MDEIKEEDKG
     ETEEHPQQEK PKESADSESC GQVVLQLWRD FCQCYSSRQL LYWSLWWAMA TCGYNQTVNY
     VQVLWEHVQP SQNFSIYNGG VEAASNLLSE RPHPQNSPHQ TELCSKLPSS CRCRHCLQRR
     LHRGQVGAVG GAGPGGFLWT GSRRAVSHDF RWKHLGVLLR LCRLQVPVHA AHNDSNVPDC
     SRAVDGKVRA CVWGKHVWSS GSPNHHHVCG GGQRRARPDH HSSVHHICKL LPGHLCGFYS
     SGAL
//