ID A0A3B3BDD8_ORYME Unreviewed; 1073 AA.
AC A0A3B3BDD8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Protein tyrosine phosphatase receptor type N2 {ECO:0000313|Ensembl:ENSOMEP00000003212.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000003212.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000003212.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004212}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004212}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 8 subfamily. {ECO:0000256|ARBA:ARBA00025723}.
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DR AlphaFoldDB; A0A3B3BDD8; -.
DR STRING; 30732.ENSOMEP00000003212; -.
DR PaxDb; 30732-ENSOMEP00000003212; -.
DR Ensembl; ENSOMET00000011214.1; ENSOMEP00000003212.1; ENSOMEG00000004127.1.
DR GeneTree; ENSGT00940000154095; -.
DR OMA; MEANREP; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.70.2470; Protein-tyrosine phosphatase receptor IA-2 ectodomain; 1.
DR InterPro; IPR033522; IA-2/IA-2_beta.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR021613; Receptor_IA-2_dom.
DR InterPro; IPR038112; Receptor_IA-2_ectodomain_sf.
DR InterPro; IPR029403; RESP18_dom.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46106; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR PANTHER; PTHR46106:SF5; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2; 1.
DR Pfam; PF11548; Receptor_IA-2; 1.
DR Pfam; PF14948; RESP18; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SMART; SM01305; RESP18; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1073
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017467356"
FT TRANSMEM 665..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 798..1044
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 977..1045
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 353..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1073 AA; 119455 MW; 64284AF63089101F CRC64;
MDSRWCPIFF TALAVSLCSS PVLADRKFGC LFQDELCEPY EFCVNDGVFG RCQQLAGADL
HTYDISASAL QRLRIILQKL AQRGLKWEDD TTQRVISREL SKLRNVPFHH QSNSPSLLDI
YSNSRDRKLK PDQTDLNRNL QKYLTEFLQP LDHQPQVQQE GPKVQHEDMV SDALSAPGRP
KPKQGWKETT IYSLQKGAGQ PPVSKVITKS GEGRHPKLST AYSIQDPHSS KHISNHLEQL
LTGASGKQQG DGEAVWPKGK LQYLGYLRPA QSNQAEPQTS AFGSKTSKLD LDGLLFKAGS
DRLAAKKPLD GTNERLVSNA VNQLGRHSFN MEDLIGKDLH HLAEVITGAL QEVDEERPEL
GARPASGASG SRGEMEANHE QLMAKLLNPD QALKSEKGQD PNQKNTLGTK QGQQTGGSDK
ESTDKKHGLF FSKLLDYLNM EPFGDAPGLD RVSPGLVHKT AGLENVQSRT TQGQAPVPNR
SEEKTLTVPA KEGSVLRLMG GAEMPDAQVD SEMERWMQAD QAPVERKKPV EPQKADMKIK
TQLVHVGVKE FSSRGKDRHF GYIITGSDSL TNDQGLELME RLTQRLSLHA SDLTQLSVLG
PALTFRVGPN PRNVTTADLV QLAVQQKLQL EKETGLKIVE AGVSDRGSLT QIPVVKETRV
ESGQFLLLSI LCVLFILVAV AVSATFFCVR QRSHLHMKEK LASLGTDTST DATATYQELC
RQRMAIRTSE RVERPETLRH SRLNSVSSQF SDGPAASPST RSSTSSWCEE PVPSNMDIST
GHMILSYMED HLKNKNRLER EWEALCSYQA EPSACSVGQG EQNSKRNRSG GVVAYDHSRI
TLKAENNHGN SDYINASPIM DHDPRNPTYI AAQGPLASTV ADFWQMVWES GCVVVVMLTP
LCENGVKQCH HYWPDEGSDV YHIYEVNLVS EHIWCEDFLV RSFYLKNLQT NETRTVTQFH
FLSWMDRGIP TSARTLLDFR RKVNKCYRGR SCPIIVHCSD GAGRSGTYIL IDMVLNRMAK
GAKEIDIAAT LEHLRDQRAG MVQTKLVSEV DQRGRRMMAG LYSDVQSYFS LLI
//
