ID A0A3B3BE76_ORYME Unreviewed; 1978 AA.
AC A0A3B3BE76;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Ankyrin 3 {ECO:0000313|Ensembl:ENSOMEP00000003911.1};
GN Name=ANK3 {ECO:0000313|Ensembl:ENSOMEP00000003911.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000003911.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000003911.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR Ensembl; ENSOMET00000010041.1; ENSOMEP00000003911.1; ENSOMEG00000004945.1.
DR GeneTree; ENSGT00940000154939; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24198; ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24198:SF173; ANKYRIN-3; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 6.
DR Pfam; PF13606; Ank_3; 1.
DR Pfam; PF13637; Ank_4; 2.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 22.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 21.
DR PROSITE; PS50088; ANK_REPEAT; 21.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 47..79
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 80..112
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 113..145
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 146..169
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 208..240
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 241..273
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 274..306
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 307..339
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 340..372
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 373..405
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 406..438
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 439..471
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 472..504
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 505..537
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 538..570
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 571..603
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 604..636
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 637..669
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 670..702
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 703..735
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 736..768
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 972..1127
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1129..1276
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1465..1549
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1599..1738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1755..1855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1906..1978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1606..1640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1673..1687
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1800..1817
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1818..1844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1955..1978
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1978 AA; 215696 MW; 4FF99A9FDDEE5C7F CRC64;
MASVIAVREQ QPTDVNACYL RAARAGNLEK ALDYLQNGVD INICNQNGLN ALHLASKEGH
VEVVAELIKQ GANVDAATKK GNTALHIASL AGQTEVVKEL VSNGANVNAQ SQNGFTPLYM
AAQENHLDVV QLLLDNGSSQ SIATEDGFTP LAVALQQGHD HVVSLLLEND TKGKVRLPAL
HIAARKDDTK AAALLLQNDH NADVESKSGF TPLHIAAHYG NINVATLLLN RGAAVDFKAR
NDITPLHVAS KRGNSNMVRL LLERGSKIDA RTKDGLTPLH CAARSGHEQV VEMLLNRGAP
ILSKTKNGLS PLHMATQGDH LNCVQLLLHH DVPVDDVTND YLTALHVAAH CGHYKVAKVI
VDKKANPNAK ALNGFTPLHI ACKKNRVKVM ELLLKHGASI QAVTESGLTP IHVAAFMGHE
NIVHQLINHG ASPNTSNVRG ETALHMAARA GQSNVVQYLV QNGARVDAKA KDDQTPLHIS
SRLGKQDIVQ LLLANGADPD ATTNSGYTPL HLAAREGHKD IAATLLDHGA NLSVTTKKGF
TPLHVAAKYG KIEVANLLLQ KKAPPDAAGK SGLTPLHVAA HYDNQKVALL LLNQGASPHS
SAKNGYTPLH IAAKKNQMEI STTLLEYGAL TNTVTRQGIT PLHLASQEGS VDIVTLLLAR
GSPINAGNKS GLTPLHLAAQ EDKVNVAEVL VNHGAVVDPE TKLGYTPLHV ACHYGNIKMV
SFLLKHQANV NAKTKNGYTP LHQAAQQGHT HIINLLLHHG ASPNELTANG NSALSIARRL
GYISVVDTLK VVTDETLTSQ TVVEKHRMNV PETMNEVLDM SDEDVFKANF PEMITDDYFS
DVEEGDDVMT GDTDKYLAPQ DLRELGDDSL PQEGYMGFSV GARSQSLRSF SSDRSNTLNR
SSFTRDSMMI EEMLAPHKET MLCKERSFIV EQHKKHLSMT KDADSDSMKR YSWTPDTLDN
VNLVSSPIHS GFLVSFMVDA RGGSMRGSRH NGMRIVIPPR KCTAPTRITC RLVKRHKLAS
PPPMVEGEGL ASRLVEVGPA GAQFLGPVIV EIPHFGSMRG KERELILLRS ENGESWKEHL
YDCKTEDLNQ LLNGMDEELD SPEELERKRI CRIITKDFPQ YFAVISRIRQ ETHHMGPEGG
TLCSRSVPLV QASFPEGALT KKIKVGLQAQ PIPEDTVKKM IGNRATFSPI VTVEPRRRKF
HKPITMTIPI PPLSGEGSTN GYKGDSTPCL RLLCSITGGT SPAQWEDITG TTPLTFVDDC
VSFTTNVSAR FWLADCHQTA ETVGLATQLY RELICVPYMA KFVVFAKMND SVESSLRCFC
MTDDKVDKTL EQQENFEEVA RSKDIEVLEG RPIYVDCYGN LTPLTKAGQQ LVLNFYAFKE
NRLPFCVKVR DPSQEPCGRL TFLKDSRTIK GLPQTAVCNL NITLPAVKKT EKPDRRQTFA
SLALRKRYSY LAEPALSPQS PCERTNVRMA IVAEHLGLSW TELARELNFS VEEINSIRVE
NPNSLTAQSF MLIKKWVHRD GKNATTDVLT TVLTKINRLD IVTLLEGPIF DYGNISGTRC
FADDNPVFPD QSDGYHSIDL ELQTPTELNF VPPTPLRCDD FFSDGDTSLE SPSKTPLTRP
SDLSLAQTTS TSSSDPPTVA PGPASNAKKP PIVGPEDTTL QDAGNPLERP DNNRLTTKQR
KMDKDPTTAQ AAPEIKENAG NGKEEEEEEE EMTQDRLRSL LQDIQLEGGV EEEEMTEEKV
HAILEQVRQA EKDLSSVAGW TGETSGAFGE SAAVSHNGDG EEGSPEKPAD PLERPAAQNG
RHSQEAKEGR GKEVTGEGLQ DDSSSAGPSR TEADRSQHQV QGNVIAEESD EDATITTTVY
RRRVILKGEE ARNIPEDSVT EEQFTDEDGN LVTRKVIRKV VRRVFNSQER KEGEITEQEG
VGVGGAAGGG EAAGTAAKSS GGKGKKRVKR SRHGHKEEAQ RGKAESGVSG SKKQEKKL
//
