ID   A0A3B3BEH9_ORYME        Unreviewed;       829 AA.
AC   A0A3B3BEH9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000003433.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000003433.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   AlphaFoldDB; A0A3B3BEH9; -.
DR   STRING; 30732.ENSOMEP00000003433; -.
DR   PaxDb; 30732-ENSOMEP00000003433; -.
DR   Ensembl; ENSOMET00000010834.1; ENSOMEP00000003433.1; ENSOMEG00000004371.1.
DR   GeneTree; ENSGT00950000182881; -.
DR   OrthoDB; 1967517at2759; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF21; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 3; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        400..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        445..463
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        539..562
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        568..592
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        633..656
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        761..785
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   REGION          672..697
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          99..126
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   829 AA;  94185 MW;  E14D097CBCB8772E CRC64;
     MGSMFRSEEV CLVQLFLQSG SAYNCVSELG ELGLVEFRDL NPNVNAFQRK FVGEVRRCEE
     LEKTFTFLEQ EISRSLSPPL QGPLPLPCPM PSAPQPRELI TIEEESERLA RELKEVSRNR
     DSLRAQLTQL CQYKGVLNKT HSITASHAPP PALENHGLFD NRQDVRLSFV AGVVHPWKVP
     SFERLLWRAC RGYIIVDFRE MDQRLEHPDT GEMVQWTVFL ISFWGDQIGQ KVKKICDCFH
     TQTFAYPESP AEREEILQGL NTRIEDIKSV LSQTESFLQQ LLLRAVAILP QWKVRVQKCK
     AIQMVLNLCS PSVTDKCLIA EAWCPTAKLP ELQSALREGG RKSGSGVDSF YNRLPTSTPP
     PTLFPLNSFT AGFQNIVDAY GVAGYREVNP AVYTIITFPF LFAVMFGDVG HGILMSLAAL
     WMVLEEKDPK LKNSNNEIWK MMFGGRYLIL LMGLFSIYTG AIYNECFSRS LSTFASGWHV
     GPMFDKNIWN TSVLEGNKFL SMDPAVSGVF TSPYPFGIDP VWGMANNKLT FLNSYKMKMS
     IIIGVIHMTF GVCLSFFNYW HFKKISSVFF ILIPELFFML CLFGYLVFMV VFKWIAYTPD
     QSKIAPSILI HFINMFLFID NPDNPQLYKG QLVVQKVLVV LALCSVPVLL LGKPIWQYVT
     FKRRRQHLQH QDEDRRPLVT EDGSVNTRQG EVEGGAPAEE EEFDVADVFM HQAIHTIEYC
     LGCISNTASY LRLWALSLAH AQLSEVLWTM VMHMALRWPG YVGSAVLVLI FVFFAVLTVS
     ILLVMEGLSA FLHALRLHWV EFQNKFYSGD GYKLMPFSFT SLIHASAAI
//