ID A0A3B3BET8_ORYME Unreviewed; 415 AA.
AC A0A3B3BET8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Lysine (K)-specific methyltransferase 2E {ECO:0000313|Ensembl:ENSOMEP00000003717.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000003717.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000003717.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3BET8; -.
DR STRING; 30732.ENSOMEP00000003717; -.
DR PaxDb; 30732-ENSOMEP00000003717; -.
DR Ensembl; ENSOMET00000010372.1; ENSOMEP00000003717.1; ENSOMEG00000004627.1.
DR GeneTree; ENSGT00940000157862; -.
DR OMA; KPECISI; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd15550; PHD_MLL5; 1.
DR CDD; cd19182; SET_KMT2E; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR044434; KMT2E_SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46462:SF2; INACTIVE HISTONE-LYSINE N-METHYLTRANSFERASE 2E; 1.
DR PANTHER; PTHR46462; UPSET, ISOFORM A; 1.
DR Pfam; PF20826; PHD_5; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 37..85
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 239..356
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 415 AA; 47084 MW; F7CD5C9BAE25301F CRC64;
MLIRQGEGGL FVTGGQDEAS RGTTLSTSED GSYGADITRC ICGFTHDDGY MICCDKCSAW
QHIDCMGIDR QNIPETYLCE RCQPRHLDRE RAILLQTRKR ECLSDGDTSA TESGDEVPLE
LYSTFQHTPT TITLTTGRLG NKQVDKKRKK SGDKDPPAPS AKAKKSKGKQ LKPSRGAAPE
VEPVEHPSLW ENKIKTWMER YEEANSNQYS EDVQLLLRVK EQGDGRSLAY NTHPASFKPP
VESQVQKNKK ILKAVRDLAP DSLIIEYRGK FMLRQQFEAN GYFFKRPYPF VLFYSKFDGL
EMCVDARSFG NEARFIRRSC TPNAEVRHVI EDGMLHLYIY SLRHITKGTE ITIGFDFDYG
NCKYKVDCAC VKGNQECPVL KHNQEPTENM GAGGKRRGSL DKKKLAKNIR MLLKY
//
