ID A0A3B3BFE9_ORYME Unreviewed; 358 AA.
AC A0A3B3BFE9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Homer protein homolog 1-like {ECO:0000313|Ensembl:ENSOMEP00000004200.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000004200.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000004200.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Postsynaptic density {ECO:0000256|ARBA:ARBA00034105}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the Homer family.
CC {ECO:0000256|ARBA:ARBA00023606}.
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DR AlphaFoldDB; A0A3B3BFE9; -.
DR STRING; 30732.ENSOMEP00000004200; -.
DR PaxDb; 30732-ENSOMEP00000004200; -.
DR Ensembl; ENSOMET00000009562.1; ENSOMEP00000004200.1; ENSOMEG00000005157.1.
DR GeneTree; ENSGT00940000156354; -.
DR OMA; HFFLAPF; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR GO; GO:0035256; F:G protein-coupled glutamate receptor binding; IEA:InterPro.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0061061; P:muscle structure development; IEA:Ensembl.
DR CDD; cd01206; EVH1_Homer_Vesl; 1.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045027; Homer.
DR InterPro; IPR044100; Homer_EVH1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR10918; HOMER; 1.
DR PANTHER; PTHR10918:SF3; HOMER PROTEIN HOMOLOG 1; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50229; WH1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 1..110
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT REGION 115..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 183..328
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 144..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 358 AA; 40759 MW; 2496D3A420234DA8 CRC64;
MGEQPIYSTR AHVFQIDPNT KKNWLPTSKH AVTVSYFYDS TRNVYRIISL DGTKAIINST
ISPNMTFTKT SQKFGQWADS RANTVYGLGF STEHHLSKFA EKFAEYKEAA RLAKEKSQEK
MEMATSPSQE SPAGELASPL TPVTPPMETI NGTDELCDTT PNSDSRPEPA QNALAFAHSP
AMTKHWEAEL EALKGNNAKL TAALLESTAN VKQWKQQLAA YQEEAERLHK RVTELECQSN
QTPVIKSQKT ELNQTIEELE NTLRDKEEEM EKLKEELENM NDLMEQKDTL TQKLEETELR
SRVLEEQLAG AEQRLEENQE EQENFRKSLR TLLEVLDGKI FELTELRDTL ARLIEEAS
//
