ID A0A3B3BFJ7_ORYME Unreviewed; 788 AA.
AC A0A3B3BFJ7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000004250.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000004250.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3B3BFJ7; -.
DR STRING; 30732.ENSOMEP00000004250; -.
DR PaxDb; 30732-ENSOMEP00000004250; -.
DR Ensembl; ENSOMET00000009473.1; ENSOMEP00000004250.1; ENSOMEG00000005200.1.
DR GeneTree; ENSGT00940000159781; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24044:SF380; DELTA-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 5.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 6.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 8.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|RuleBase:RU280815};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815}.
FT DOMAIN 167..211
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 278..316
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 318..354
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 356..393
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 395..431
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 436..472
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 474..510
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 528..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 169..178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 182..194
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 202..211
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 306..315
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 344..353
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 383..392
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 421..430
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 462..471
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 500..509
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 788 AA; 86339 MW; C136175C0D4CB286 CRC64;
MKFVFQVLCS GVFELKLQEF LNKKGISGNA NCCPGGSAHP QGHQQCECKT FFRVCLKHYQ
ANVSPEPPCT YGGAVTPVLG SNSFQVPETN ADSFTNPIRF PFGFTWPGTF SLIIEALHTD
SLDDLTTENP ERLISRITTQ RHLSVGEEWF KDMQTADRTE LRYSYRFLCD EHYYGDGCSV
FCRPRDDAFG HFTCGERGEI ICNSGWKGQY CTDPICLPGC DEEHGFCDKP GECKCRVGFS
GRYCDDCIRY PGCLHGTCQQ PWQCNCQEGW GGLFCNQDLN YCTHHKPCLN GATCTNTGQG
SYTCTCLPGY TGASCEIQVS ECSGNPCRNG GSCSDNDNGY KCACPPGFYG NNCELSANTC
ADGPCFNGGR CADNPEGGYF CQCPAGYAGF NCEKKIDHCS SNPCLNGAEC VDLVNSYLCR
CPEGFIGSNC EVRSSISGHC QSFPCQNGGT CQDGGNDYSC TCPPGYTGKN CSSPVSRCHH
NPCHNGATCH ERGGRYVCAC VPGYGGHNCQ FLLPEMSGGS QPVVDVADRR YSSSESENSE
DSEDDESGFP WAAVCAGIFL VLVVLISCSV LVVYVRVKLQ DRLSHHSDSV HSDSQETMNN
LTTTNNCLRS DKELGPMMTT SIKNTNKKAD YHSDLAGSLV GLSGINGSEK NGFKTRYPSV
EYNLVHELRS EEPSLCKEDE PNEPEAKCEM LEEFNTEEGF RKTQNSNASE KQLTESTGCS
EERYQSSTDL GCHSASDLKY HSTNDVKFQS GNDESPDDSQ YSCLPDTKYQ SVYVMSDQKD
ECVIATEV
//
