ID A0A3B3BG10_ORYME Unreviewed; 790 AA.
AC A0A3B3BG10;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Glucocorticoid receptor {ECO:0000256|ARBA:ARBA00015625};
DE AltName: Full=Nuclear receptor subfamily 3 group C member 1 {ECO:0000256|ARBA:ARBA00031162};
GN Name=NR3C1 {ECO:0000313|Ensembl:ENSOMEP00000004516.1};
GN ORFNames=FQA47_022989 {ECO:0000313|EMBL:KAF6720221.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000004516.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000004516.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|EMBL:KAF6720221.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bigg-433 {ECO:0000313|EMBL:KAF6720221.1};
RX PubMed=32938378;
RA Liang P., Saqib H.S.A., Ni X., Shen Y.;
RT "Long-read sequencing and de novo genome assembly of marine medaka (Oryzias
RT melastigma).";
RL BMC Genomics 21:0-0(0).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm,
CC cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173}. Nucleus
CC {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC subfamily. {ECO:0000256|ARBA:ARBA00005413}.
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DR EMBL; WKFB01000528; KAF6720221.1; -; Genomic_DNA.
DR STRING; 30732.ENSOMEP00000004516; -.
DR PaxDb; 30732-ENSOMEP00000004516; -.
DR Ensembl; ENSOMET00000009040.1; ENSOMEP00000004516.1; ENSOMEG00000005484.1.
DR GeneTree; ENSGT00940000156385; -.
DR OMA; MEDTEIW; -.
DR OrthoDB; 5305911at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR Proteomes; UP000646548; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0042562; F:hormone binding; IEA:UniProt.
DR GO; GO:0004883; F:nuclear glucocorticoid receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0005496; F:steroid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd07172; NR_DBD_GR_PR; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR001409; Glcrtcd_rcpt.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR48092:SF5; GLUCOCORTICOID RECEPTOR; 1.
DR PANTHER; PTHR48092; KNIRPS-RELATED PROTEIN-RELATED; 1.
DR Pfam; PF02155; GCR; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000646548};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 425..509
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 537..771
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
SQ SEQUENCE 790 AA; 86109 MW; 61AA693A2CAB3EB3 CRC64;
MFLSQQNEEM DQGELKLNGN QGGSLSFGEI GPEACGDTGD SSDLLFQSAM HLPGSGSVAP
NGQGGTKGQG EVGGFFEPPE SSEVKGDKLI RMQKSEQNVF SMGENLPLVS ESISDPKQAP
PCVISASDRS VLGGLPLPDL FSQHIKQEGM FYMDKDLGAY SGQTGSGLCD LDSNSTPLID
DAEIWRDLDL TSSLEEISAL ELDSEVAHLD NILQDSNGAG VDSSSGLLKE TKSLMGNGAN
FTSVNGTEQQ QHRHQQPPLH LAQHHQQLQP ILSSVVIKEE KDPDFIHIRT PGVVKQEKQD
SYCQSQCLQS GMSSLHGGAG GGALSSSVCL GAGSGYPYRA SPSSTVTLQD QKPFGIYPNQ
PLVGERWIEG KGYGESSGKP SSGDGLASAS GLPGFPASFS SSSSRAAESG SAVGSGHSKP
SGQTHKICLV CSDEASGCHY GVVTCGSCKV FFKRAVEGWR ARQNTDGQHN YLCAGRNDCI
IDKIRRKNCP ACRFRKCLQA GMNLEARKNK KLIKMKRPAG SSEPVNNNLP VPIIPRSMPQ
LVPTMLSVLK AIEPEIIYSG YDSTLPDTSS RLMTTLNRLG GQQVISAVKW AKSLPGFRNL
HIDDQMTLLQ CSWLFLMSFS LGWRSYEQCN GSMLCFAPDL VINTDRMQLP FMTDQCEQML
KICKEFVRLQ VSYDEYLCMK VLLLLSTVPK DGLKSQAVFD EIRMAYIKEL GKAIVKREEN
ASQNWQRFYQ LTKLLDSMQE MVEGLLQICF YTFVNKTLSV EFPDMLAEII TSQIPKFKDG
GVKALLFHQK
//
