ID A0A3B3BIM7_ORYME Unreviewed; 1053 AA.
AC A0A3B3BIM7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=RAS p21 protein activator 1 {ECO:0000313|Ensembl:ENSOMEP00000005335.1};
GN Name=RASA1 {ECO:0000313|Ensembl:ENSOMEP00000005335.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000005335.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000005335.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B3BIM7; -.
DR STRING; 30732.ENSOMEP00000005335; -.
DR PaxDb; 30732-ENSOMEP00000005335; -.
DR Ensembl; ENSOMET00000007653.1; ENSOMEP00000005335.1; ENSOMEG00000006347.1.
DR GeneTree; ENSGT00940000155846; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
DR GO; GO:0048013; P:ephrin receptor signaling pathway; IEA:Ensembl.
DR CDD; cd08400; C2_Ras_p21A1; 1.
DR CDD; cd13260; PH_RASA1; 1.
DR CDD; cd05391; RasGAP_p120GAP; 1.
DR CDD; cd10354; SH2_Cterm_RasGAP; 1.
DR CDD; cd10353; SH2_Nterm_RasGAP; 1.
DR CDD; cd11788; SH3_RasGAP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR035842; RasGAP_C_SH2.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR035841; RasGAP_N_SH2.
DR InterPro; IPR035652; RasGAP_SH3.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10194:SF146; RAS GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 171..262
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 269..331
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 341..431
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 464..568
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 569..682
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 740..933
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..135
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1053 AA; 118989 MW; 16E14D5FC18ED585 CRC64;
MMAAEVSGEE TVTSGTGVAG GGGPETAPFP YYSKPSRVGV TDLGQGPTQT LRQFSNTSPD
SLPDMSIMYP TSGGGDMTAS ATGGGQSGIP RTNSGSMCHS PNSEESASQF SPTSKGPDSP
TAFPPLPPPP PAPAGCAGHG VTMDESDMQD GPECEDDEVL LELSAPPTNQ WYHGKLDRTI
AEERLRQARN PGSYLIRESD RRPGSFVLSF LSVTNVVNHF RIIAMCGDYY IGGRRFSSLS
DLIGYYSYAS CLLKGEKLLL PVAPPEPVED RRRVRAILPY TKVPDTDEIS FLKGDMFIVH
NELEDGWMWV TNVRTEEQGL IVEDLVEEVG REEDPHEGKL WYHGKITKQE AYNLLMTVGQ
VSSFLVRPSD NTPGDYSLFF RTNENIQRFK ISPTPTNQYM MGGRYYNSVD DIIDHYKKEQ
IVEGYNLKEP VSVQHQEQVL TDTVDGREIY NTIRRKTKDA FYKNIVKKGY LLFNKGKGKR
WKNLYFILEG NDAQLIYFES EKRATKPKGL IDLSVCSVYC VHDSLFGRPN CFQIVVQHFS
EEQYIFYFAG ETPEQAQDWM KCLQTFCSNL RKTTVNTSNK RLRQVSSLVL YVEEAHKLPV
KHFTNPYCNI YLNNVQVAKT HPREGQNPVF TEEFIFDDLS GEINRFEISL SNKTKKSKEI
DILFMRCQLN RLQKGQMIDE WFPLSSHIPL KGIEPGSLRV RARYSVEKIM PEEEYSDLKE
MILQKDFHVI YALAHVCGQD RSLLASLLLR IFRHEKAEAP LLRTLNDREI NMEDEATTLF
RATTLASTLM EQYMKATATP FVLHALKDTI LKIMESKQSC ELNPSKLEKN EDVNLNLAHL
LNILSELVEK IFLAAEILPP TLRFIYGCLQ KSVQRKWPNT TMRTRVVSGF VFLRLICPAI
LNPRMFNIID DPPSSTAGRT LTLVAKSVQN LANLVEFGAK EPYMEGVNPF IKCNKQRMIM
FLDELGNVPE LPETTEHFRT DLPRDLAALH EVCVAHSDEL RTLSNERGAQ QHVLKKLLAI
TELLQQKQAQ YAMSNSNRTE CTIMSLAAAI QVM
//
