ID A0A3B3BMS8_ORYME Unreviewed; 1342 AA.
AC A0A3B3BMS8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Adenosine deaminase RNA specific {ECO:0000313|Ensembl:ENSOMEP00000006876.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000006876.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000006876.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR SMR; A0A3B3BMS8; -.
DR STRING; 30732.ENSOMEP00000026265; -.
DR PaxDb; 30732-ENSOMEP00000026265; -.
DR Ensembl; ENSOMET00000005000.1; ENSOMEP00000026265.1; ENSOMEG00000008019.1.
DR Ensembl; ENSOMET00000005071.1; ENSOMEP00000006876.1; ENSOMEG00000008019.1.
DR GeneTree; ENSGT00940000157243; -.
DR OrthoDB; 118472at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0003726; F:double-stranded RNA adenosine deaminase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd19915; DSRM_DRADA_rpt3; 1.
DR Gene3D; 3.30.160.20; -; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR002466; A_deamin.
DR InterPro; IPR044457; ADAR1_DSRM_3.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR042371; Z_dom.
DR PANTHER; PTHR10910:SF107; DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE; 1.
DR PANTHER; PTHR10910; EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN; 1.
DR Pfam; PF02137; A_deamin; 1.
DR Pfam; PF00035; dsrm; 3.
DR Pfam; PF02295; z-alpha; 2.
DR SMART; SM00552; ADEAMc; 1.
DR SMART; SM00358; DSRM; 3.
DR SMART; SM00550; Zalpha; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 3.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR PROSITE; PS50137; DS_RBD; 3.
DR PROSITE; PS50139; Z_BINDING; 2.
PE 4: Predicted;
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}.
FT DOMAIN 239..302
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 391..455
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 587..655
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 717..785
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 843..911
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 979..1311
FT /note="A to I editase"
FT /evidence="ECO:0000259|PROSITE:PS50141"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1342 AA; 146967 MW; E8BA5C18C1D5F58A CRC64;
MSRGRGGSYK EHPHRHIPPN LQVKENYYRP GAAQLFPRDD PDQIPNRHYS NSPGCPSVPL
GSPSPLLPSA PPIPNQFNVS NSGAFNCSYN QNQGFGPIPN SFHYKQVEFL RGHTSEAPQF
RGGVRAIGSR PPNYTHQPQP HYNRYSNPNS SPRSRGYYRE CYRQDQSYSF PSPSGLSQGF
ARPQYPNANQ SRGVNHQLSD RQTSFLCDNF QRLNLQQDRG CRKSFDGRSS SGKYSKAKIT
LTPVIQEQVY KALTADEAVS ARVLAKKLHL PKKVINQALY SLEQSKKASK QGLQPPEWTL
YRENPQAEET TSAQPQNPPS LLSFSSIQLQ SAEAKVDIEK EQEIEEEDSD AESSSSCSSL
EFSASEDSQS SANVGCQESP RASSADLKFS SAMMADQKEK ILKYLLESGE ATALVLAKNL
GLKGAKQVNP TLYDLEKQGE VVKTETSPYK WKLSPHRRER MERSLKAASI PQAGQMEVDV
KTEQDDGGPI LTPLSGLEPI PNMENWTPEQ PQGKMKSSFS PYEDNANNES QWANDSIPDY
LNAIRRHTDA IKLAAEKGNT VGTVAVSLAA PPSQNLWAKL QEVRLKNPVS GLMEYAQYLG
QSCEFLLLDQ SGPSHDPRFR MQVMLNGRLF PIAEASNKKV AKKDAAAATL RILIKEMQGG
ESAADEDNTA SMDREPDQLP DTSGSAENTQ GGSGSGGAEG AEGPRQPLSR SLPGGKNPVS
VLMEYSQRSG KPIEFIATGQ TGPPHDPRFK YRVKVGENLF AESSAPSKKA ARQLAAEEAV
KELMADGKLQ LNKPLLPLGP SSDGEEGSSS GAACPSLPPL TADELRAAHE AGVGDLINHL
NNNAVSGLLE YARARGFAAE IRLVGQSGPP HEPKFTYQAK LGGRWFPPVC ASNKKQGKQE
AADAALRVLI GEAERAARTG ELIPSELPVS GSTLHDQIAM LSHQRFNALT TRIQHCLLGR
KILATIVMRR GEGLGTVVSL GTGNRCVKGE ELSLKGETVN DCHAEIISRR GFIRFLYNEL
LKHYDGTDDS IFEPADGNKL QIKSDITFHL YISTAPCGDG ALFDKSCSET GDEVPGHQPL
FENVKQGKLR TKVENGEGTI PVESSDIVPT WDGIQHGERL RTMSCSDKIL RWNVLGLQGA
LLTHFLHPIY LKSITLGYLY SHGHLTRAVC CRLARDGEAF DQSLPRPFTL NHPEVGRVSV
YDSTRHTGKT KESSVNWSLP DQYNVEVLDG TKGTLDGNKQ AVSRVSKSNL FCLFRSLCQK
SNRADLLSLP SYAQAKMSAT SFQLAKQQFF QALSVHGYGA WIGKPLEEKS FESLEATRNN
GACSSVEFGR NEGAVDYKPA EA
//
