ID A0A3B3BN14_ORYME Unreviewed; 634 AA.
AC A0A3B3BN14;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Prolactin receptor {ECO:0000256|RuleBase:RU365035};
DE Short=PRL-R {ECO:0000256|RuleBase:RU365035};
GN Name=PRLR {ECO:0000256|RuleBase:RU365035};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000006522.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000006522.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: This is a receptor for the anterior pituitary hormone
CC prolactin. {ECO:0000256|RuleBase:RU365035}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU365035}; Single-
CC pass type I membrane protein {ECO:0000256|RuleBase:RU365035}.
CC -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
CC folding and thereby efficient intracellular transport and cell-surface
CC receptor binding. {ECO:0000256|RuleBase:RU365035}.
CC -!- DOMAIN: The box 1 motif is required for JAK interaction and/or
CC activation. {ECO:0000256|RuleBase:RU365035}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 1
CC subfamily. {ECO:0000256|RuleBase:RU365035}.
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DR AlphaFoldDB; A0A3B3BN14; -.
DR STRING; 30732.ENSOMEP00000006522; -.
DR PaxDb; 30732-ENSOMEP00000006522; -.
DR Ensembl; ENSOMET00000005660.1; ENSOMEP00000006522.1; ENSOMEG00000007593.1.
DR GeneTree; ENSGT00940000154851; -.
DR OMA; KQHCLSD; -.
DR OrthoDB; 5312906at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR015152; Growth/epo_recpt_lig-bind.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF86; PROLACTIN RECEPTOR; 1.
DR Pfam; PF09067; EpoR_lig-bind; 1.
DR SMART; SM00060; FN3; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU365035}; Membrane {ECO:0000256|RuleBase:RU365035};
KW Metal-binding {ECO:0000256|RuleBase:RU365035};
KW Receptor {ECO:0000256|RuleBase:RU365035};
KW Signal {ECO:0000256|RuleBase:RU365035};
KW Transmembrane {ECO:0000256|RuleBase:RU365035};
KW Transmembrane helix {ECO:0000256|RuleBase:RU365035};
KW Zinc {ECO:0000256|RuleBase:RU365035}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|RuleBase:RU365035"
FT CHAIN 24..634
FT /note="Prolactin receptor"
FT /evidence="ECO:0000256|RuleBase:RU365035"
FT /id="PRO_5017105326"
FT TRANSMEM 238..256
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365035"
FT DOMAIN 28..129
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 131..230
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 634 AA; 72432 MW; 92B20A6DE4A078C6 CRC64;
MMKNDGGVIL FWLLLLFTLY ARGKSYSVPG KPTLTRCRSP EKETFTCWWE PSSDGGLPTT
YKLYYRKEDS SDVEYECQDY RTGGKNSCFF NKNYTSIWVN YNITIVAINA LGQTFSDPVD
IDVYYIVEPN PPENLNVTIQ NDKGWPFLRA SWDPPKKADT RSGWITLIYE LRIKLEEEDE
WEIRDVGQQK VFNIYGLQSE GTYVVQIRCR PDHGFWSEWS ADVQVKVPNY LRRNRSTWIM
IIVFSAVVFL ILSWLLHINS RNLKHCLLPP VPGPKIKGFD KKLHKSGKSL DAFKSLDVPD
FPHHTFSKSE DLLVEFIEVY VPEEQELMLE KSNDLHDGCL KSESSVSDCD SGRGSCDSHT
LLLDKSGQQT DTQDSQIDEQ RLGEDLQDEK LSYAHQDMVS PDMSAGRVKT WPSVFSPLPQ
NRSTSADQAS SLEMAKQHCL SDSLLPSEFL TSYHSLSGHG TRDHLGSNYW EFNFGNKRPN
LTQPQTEARH QAHSEINIFT TGVKAEPTAL KFPTPRSSDY VEVQRVNEED SIVLRPVGSN
YDKHFEIQQG EEYSRVKGVD SDNVLLLLQK EAMEEEMDMC PCEQLSGTTE AHYTKFSTSP
EKPTAYTHPT PQPLEERVVN GYVDTATMFT MPPY
//