ID A0A3B3BNN5_ORYME Unreviewed; 1188 AA.
AC A0A3B3BNN5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Desmoglein-2-like {ECO:0000313|Ensembl:ENSOMEP00000006593.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000006593.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000006593.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of intercellular desmosome junctions. Involved in
CC the interaction of plaque proteins and intermediate filaments mediating
CC cell-cell adhesion. {ECO:0000256|RuleBase:RU004358}.
CC -!- SUBCELLULAR LOCATION: Cell junction, desmosome
CC {ECO:0000256|ARBA:ARBA00004568}. Cell membrane
CC {ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|RuleBase:RU003318}.
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DR AlphaFoldDB; A0A3B3BNN5; -.
DR Ensembl; ENSOMET00000005540.1; ENSOMEP00000006593.1; ENSOMEG00000007667.1.
DR GeneTree; ENSGT01030000234624; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 4.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR009122; Desmosomal_cadherin.
DR PANTHER; PTHR24025; DESMOGLEIN FAMILY MEMBER; 1.
DR PANTHER; PTHR24025:SF1; DESMOGLEIN-2; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 4.
DR PRINTS; PR00205; CADHERIN.
DR PRINTS; PR01818; DESMOCADHERN.
DR SMART; SM00112; CA; 4.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1188
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017400921"
FT DOMAIN 61..142
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 142..251
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 252..339
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 449..560
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 362..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1135..1176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1188 AA; 126235 MW; E72B45F233697E95 CRC64;
MARLFQSVLV VLVLVQVAIV VRQTSGKNLV RKKREWILPP KPLKENKDYT KELSIAKIRS
DFQQDQKVEY YLEGPGANQK PFNVFVVNHE TGDVRVTKIL DREEVDTYAL KGIAKYANGS
EAERPIDLKI KVEDENDNDP VFPETLSVSV YELRPRGTFV VQVNATDADE PGNKNSELAY
SLISQNPPHD MFSINKSGMI SVKNPNLDRE RCAQYSLTVQ AKDLYGEDGG RTATGVIIIN
VLDVNDNLPT LEKLQYDGSI EENTHNVEVM RLKSNDDDLE GTDNWEAVYE IVKGNDAGYF
NIVTDPKTNE GILMLVKPVD YEDVKDLDLG IIVKNKAPPF DPSAVINGAD VNIGGGAIGA
SGASGASGAS GASGASGTNG ASGATGSGGA TGSGGPTGSG GPTGSGGATG ASGSSGGSTG
TSGGSGSIKY TSYPVKINVK NKPEGPGFEP QVKNIPISEG LDPANLKKPI ATYTAIDKDT
GKPAKNVRYL KGPDPGNWLS IDPETAEITL TKIPDRESPY LINGTYFANV LCISEDMPDK
TATGTIAIKV EDTNDNCPTL TTNSKVICLP EDSFIVNGED KDSFPNGPPL HFVIVPEKTQ
GDWKVEHLND SAVIVRAQKE LWPDSYTVEM VVSDQQGLSC KDPQKMEIVA CTCHDGVVCG
ALGGQGQSRK DITLGPAAIG LMLLGLLLLL LIPLLLLSCM CGSVGNFQDI FSSIPYGTEE
MLIKYHTEQN GENTEIPLLN TPGYLLVDSA KGHFAAAPAE LQQSFVAGNE LGTLRGYRET
GTMFSDGQWQ MNQWGSGLLS ASEVQEFGQG GEGNLALPDS YLRDYYDQRT SINRSDAVKD
SLLVFNNEGE GSLAGSLGSC SMLEQDGDLQ FLDDLEIKFK TLAEICGGKT VVSETKAVSI
PPPVASVAMP KLSESTFESN MVTTQRVAPP PSLPPTTIRE ERTVVTDTTD HSKVLREDAA
MLSEGMTSMA TGMGGQSQML VLQQQQQPVY YTAAPMLQPM QYVVQPQFQN AVILTEAPAA
GLQDVVLLNG SDIGSNPGMI IQGQTMMHSG HAQGTGTMLL ENGSNLLHMG NLSGSQAMMV
VDGTVAGSAT GVQGTLIQGG SLGSATGVQG TLIQGGSLSS GQHSGTQRVV RVEEATSGRG
RAGKSGRSSL QRIVSTKGST QTSTSSTSLS TPTNTTQKVL IQETRQIR
//
