ID   A0A3B3BNX0_ORYME        Unreviewed;       755 AA.
AC   A0A3B3BNX0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase {ECO:0000313|Ensembl:ENSOMEP00000006678.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000006678.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000006678.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B3BNX0; -.
DR   Ensembl; ENSOMET00000005399.1; ENSOMEP00000006678.1; ENSOMEG00000007833.1.
DR   GeneTree; ENSGT00390000017246; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0006047; P:UDP-N-acetylglucosamine metabolic process; IEA:InterPro.
DR   CDD; cd03786; GTB_UDP-GlcNAc_2-Epimerase; 1.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000600; ROK.
DR   InterPro; IPR020004; UDP-GlcNAc_Epase.
DR   InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR   NCBIfam; TIGR03568; NeuC_NnaA; 1.
DR   PANTHER; PTHR18964:SF149; BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE_N-ACETYLMANNOSAMINE KINASE; 1.
DR   PANTHER; PTHR18964; ROK (REPRESSOR, ORF, KINASE) FAMILY; 1.
DR   Pfam; PF02350; Epimerase_2; 1.
DR   Pfam; PF00480; ROK; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE   4: Predicted;
FT   DOMAIN          69..408
FT                   /note="UDP-N-acetylglucosamine 2-epimerase"
FT                   /evidence="ECO:0000259|Pfam:PF02350"
FT   ACT_SITE        551
FT                   /evidence="ECO:0000256|PIRSR:PIRSR620004-1"
FT   BINDING         511
FT                   /ligand="an N-acyl-D-mannosamine"
FT                   /ligand_id="ChEBI:CHEBI:16062"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR620004-2"
FT   BINDING         523
FT                   /ligand="an N-acyl-D-mannosamine"
FT                   /ligand_id="ChEBI:CHEBI:16062"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR620004-2"
FT   BINDING         551
FT                   /ligand="an N-acyl-D-mannosamine"
FT                   /ligand_id="ChEBI:CHEBI:16062"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR620004-2"
FT   BINDING         600
FT                   /ligand="an N-acyl-D-mannosamine"
FT                   /ligand_id="ChEBI:CHEBI:16062"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR620004-2"
FT   BINDING         603
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="structural"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR620004-3"
FT   BINDING         603
FT                   /ligand="an N-acyl-D-mannosamine"
FT                   /ligand_id="ChEBI:CHEBI:16062"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR620004-2"
FT   BINDING         613
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="structural"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR620004-3"
FT   BINDING         615
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="structural"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR620004-3"
FT   BINDING         620
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="structural"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR620004-3"
FT   BINDING         622
FT                   /ligand="an N-acyl-D-mannosamine"
FT                   /ligand_id="ChEBI:CHEBI:16062"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR620004-2"
SQ   SEQUENCE   755 AA;  83686 MW;  3BA529F3293C9804 CRC64;
     MEKKPAFLCR NPHELYSLRM QRNREKMERE KTEQHQNQFK RKLRVCVATC NRADYSKLAP
     IMFGIKAHSD EFELEVVVLG SHLIDDYGNT FRMIEQDDFD INSKLHTIVR GEDEAAMVES
     VGLALVKLPD VLQRLRPDIL IVHGDRFDAL ALATAAALMN IRILHLEGGE VSGTIDDSIR
     HAISKLAHYH ACCTRMAEQH LIAMCEDHSR ILLAGCPSYD KLLLTHRKDD YMDIIKSWLG
     DKVQDRDYIV ALQHPVTTDI QHSIKIYGLM LDALLSFNKK TLILFPNIDA GSKEMVRVMR
     KKGIEQHQNF RAVKHIPFEQ FIQLVCHAGC MIGNSSCGVR EAGAFGTPVI NLGTRQTGRE
     TGENVLHVRD ADTHNKIYHA LELQFGKRYP CSKIYGDGSA VPRILKFLRS IDLDEPLQKT
     FCFPPVKESI SQDIDHILET QSALAVDLGG TNLRVAIVCK RGNILKKYTE NNPKTFEDRM
     CLILKMCKDA IQDAVSINCR ILGVGVSTGG RVNPQEGVVL HSTKLIQEWS CVNLRTPISD
     ALHLPVWVDN DGNCAALAEK KFGHGKGVEN FVTVITGTGI GGGIIHHYEL IHGSTFCAAE
     LGHIMVSLEG PECSCGSRGC VEAFASGMAL QREAKMLHDE DLLKVEGIDK LCEPITAVHL
     ITAAKMGNSK AEAVLHKAST ALGVGIVNIL HVVNPSLVIL SGVLGSFYQE PVQHVINQRA
     LKSAQSIKVV SSHLEEPALL GAASMVLDYA TRRTY
//