ID   A0A3B3BNY8_ORYME        Unreviewed;       846 AA.
AC   A0A3B3BNY8;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Gamma-aminobutyric acid type B receptor subunit 1-like {ECO:0000313|Ensembl:ENSOMEP00000006862.1};
GN   Name=GABBR1 {ECO:0000313|Ensembl:ENSOMEP00000006862.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000006862.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000006862.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC       receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR   AlphaFoldDB; A0A3B3BNY8; -.
DR   Ensembl; ENSOMET00000005090.1; ENSOMEP00000006862.1; ENSOMEG00000007984.1.
DR   GeneTree; ENSGT00940000157642; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR   CDD; cd06366; PBP1_GABAb_receptor; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR002455; GPCR3_GABA-B.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR   PANTHER; PTHR10519:SF76; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   PRINTS; PR01177; GABAB1RECPTR.
DR   PRINTS; PR01176; GABABRECEPTR.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170}; Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..846
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017265462"
FT   TRANSMEM        451..476
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        488..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        527..547
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        568..591
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        680..700
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          458..722
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
FT   REGION          715..740
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          759..782
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        725..740
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   846 AA;  95800 MW;  F062D92F1AB0E56B CRC64;
     MARLRRPAAL LLSALLCFSC AADKKKKKLY IGALFPMSGG WPGGQACLPA TQMALQLVNK
     RTDILPDYEL ELIHYDSMCD PGQATKLLYD LLYTEPIKVV LMPGCSSVST LVAEAARMWN
     LIVLSYGSSS PALSNRQRFP TFFRTHPSAT LHNPTRVQLF QKWKWTKIAT IQQTTEVFTS
     TLDDLEERTK EAGIDISVRQ SFLTDPAVAV KNLKRQDARI IVGLFYETEA RKVFCEVYKE
     KLYGKKYVWF LIGWYADNWF KIKDPSINCT LEQMSEAVEG HVTTEIVMLN PETVRGASNL
     TSQEFLTQLM SKLGGKNPEE TGGFQEAPLA YDAVWALALA LNKTVGPLKA KGHRLEDFNY
     NNRDITSEIY RAMNTSSFEG VSGHVVFDAQ GSRMAWTLIE QLQGGSYKKI GYYDSTKGNL
     SWYGNDKWIG QGPPADQTVV IEEFRYLSQR LFVSMSVFAV VGILLGIVCL TFNIYNSRVR
     YIQNSQPYLN NMTAVGCMMA LAAVFPLGID GLHVHRRHFP VVCQFRLWLL GLGFSLAYGS
     MFTKIWWVHT VFTKKDEKRE KRKHLDSWKL YATVGVLLAV DVLLLMIWQI VDPLHITVEK
     FTREAPKEDL DVLIQPLLEH CSSEKMTTWL GEYLLILPFW DPDNVSKHVT LPANRFSPQV
     LCLITAPVTM ILSSQQDASF AFASLAIVFS VYITLVVLFI PKMRRLITRG EWQSDAQETV
     KSGSSTNNHD EEKSRQLERE NQELEKIIQE KEERVSELRN QLSERHALRS RKTPSTITQN
     QNHSFPLLAV TLSDPKSLAP PPGYPAPICD THPAPQSFSN SSSLYQADSK INVNNCHTSR
     LQMLYK
//