ID A0A3B3BP88_ORYME Unreviewed; 1101 AA.
AC A0A3B3BP88;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Guanine nucleotide exchange factor DBS-like {ECO:0000313|Ensembl:ENSOMEP00000007089.1};
GN Name=MCF2L {ECO:0000313|Ensembl:ENSOMEP00000007089.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000007089.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000007089.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3BP88; -.
DR Ensembl; ENSOMET00000004718.1; ENSOMEP00000007089.1; ENSOMEG00000008166.1.
DR GeneTree; ENSGT00940000157874; -.
DR OMA; NQEVETF; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01227; PH_Dbs; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd11857; SH3_DBS; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR035534; DBS_PH.
DR InterPro; IPR035532; DBS_SH3.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR22826:SF115; GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 2.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 4..186
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 586..766
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 784..900
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1003..1064
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 525..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1068..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..938
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1101 AA; 123508 MW; C28ADB75261399FD CRC64;
MGQKSSVAED VEDSVEVGDD ILQKEAGPLC AAEVGSELQK QFAILPGGRG TNGSPIIIFP
EYPDFSDLQE EELQNVLSYL TSVPSAAASG EGFILVIDRR LDRWTAVRAT LLRIAGSFPG
ILHLVLVLRP TTFFQRTISD LQLRFIRDDF KMKVPVVMLS SVTELHAYID PGQLTTEVGG
TQEYNHDSWI SHRTAIEAFA LMVKTTAQTL QAFGTELAET ELPNDAEATT NLLQVHTSKK
ELMKEDLKVA LSQGRRLLEF INEPLLADPE YSLTHDEMEN LATVQRLIGQ LDETETAFED
FWERHRTKLE QCLQLRHFEH HFREIRAQLD VMFERLSGFS EVSVSPAHAE HVLRELGNHE
EKAFELLDVA LSLASEGDRL IENSHYAEDS IRPKCSELRG VCEEISSTLR HKKGLLLRAL
ELHHALEKAS GWCEEGIFLL ASQPVDRCQS QDGAEAALQE LERYLDTAAL HTLTDCSAIC
CQYEAVLNAQ LKDQIDKVFQ KQISVQEMFE KRRISLKKLA AKQTRPVQPV APRPEVKSPL
SSPSQERKER RYSADSALCK KGESPVLNGG TRHASLSEEE ESLAVLRRHV MNELLETERA
YVEELLCVLE GYAAEMDNPA MAHLIPSTLH SKKDILFGNM SEIYQFHKRT FLKELETYTD
CPELVGRCFL ERMKDLQIYE AYCQNKPRSE SLWRQCSDCA FFQECQKKLE HKLGLDSYLL
KPVQRITKYQ LLLKELLKYS KGCDGSDDLQ EALSSILGIL KAVNDSMHLI AITGYEGNLS
ELGRLLMQGS FSVWTEHKKG HAKVKDLARF KPMQRHLFLH QKALLFCKKR EENGEGYEKA
PSYSFKHSLS MSAVGITENA KGDNKKFEIW CNSREEVFIV QAPTPEIKTA WVNEIRKVLT
QQLKACRDAR QQKSSDSVSP STTSSSSICL SPFRSNAQKN QKKQEEKKAE PSPISDTNAC
SSPKHKGWSK ASLSVDASEE NDGYSSGEDP MNSDTEEDGV KKLAPGKYTV VADCEKAGPQ
ELSVKSGDMV QLIREGEEGQ WFVKNLRTHK EGWVAAANLL SLISESKSSQ SLSSSDGSVS
GNLSTSSSCS ETYTSFSDIK P
//
