ID   A0A3B3BT09_ORYME        Unreviewed;      1030 AA.
AC   A0A3B3BT09;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Inactive ubiquitin carboxyl-terminal hydrolase 54-like {ECO:0000313|Ensembl:ENSOMEP00000008484.1};
GN   Name=USP53 {ECO:0000313|Ensembl:ENSOMEP00000008484.1};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000008484.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000008484.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C19 family.
CC       {ECO:0000256|ARBA:ARBA00009085}.
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DR   AlphaFoldDB; A0A3B3BT09; -.
DR   PaxDb; 30732-ENSOMEP00000008484; -.
DR   Ensembl; ENSOMET00000002374.1; ENSOMEP00000008484.1; ENSOMEG00000009653.1.
DR   GeneTree; ENSGT00940000156337; -.
DR   OMA; QGKNHDQ; -.
DR   OrthoDB; 453826at2759; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR   CDD; cd02257; Peptidase_C19; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR028889; USP_dom.
DR   PANTHER; PTHR22975:SF39; INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 53 ISOFORM X1; 1.
DR   PANTHER; PTHR22975; UBIQUITIN SPECIFIC PROTEINASE; 1.
DR   Pfam; PF00443; UCH; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS50235; USP_3; 1.
PE   3: Inferred from homology;
FT   DOMAIN          67..388
FT                   /note="USP"
FT                   /evidence="ECO:0000259|PROSITE:PS50235"
FT   REGION          430..534
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          555..587
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          605..633
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          648..866
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          897..937
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          977..1030
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        439..458
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        480..511
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        512..528
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        569..587
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        617..631
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        648..667
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        680..709
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        718..737
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        753..791
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        799..827
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        841..866
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        900..917
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        979..1017
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1030 AA;  115739 MW;  C693991F0E58A9D7 CRC64;
     MRWTEPMARP VHQLPCPSTS ICSKSPSNSG EAAGSNSMAW VKMFKKPGGG LKKSYQPGSM
     LSLALTKGLL NEPGQNSCFL NSAVQVLWQL DIFRRSLRQL SGHFCLGDGC IFCALKSIFS
     QFQQSRERVL PSDSLRNALA ETFKDEQRFQ LGLMDDAAEC FENILERIHL HIVSDTATDA
     CSSKSCITHQ KFAMMLYEQF VCRCCGASSD PHPFTEFVHY VSTTALCQQV DRMLGKHERL
     RSDMFGELLQ AANSTGELRS CPSDCGQSIK IRRVLMNCPE IVTIGFVWDA EQSDLTDDVI
     RSISPRLNLY GLFNRVTDEA AKRSELHLVG MICFSSKHYS AFAYHTKSSK WIFFDDATVK
     EIGSKWKDVA SKCIRGHFQP LLLFYTNPEG SPVSNEDAPR QTTMCPRYKA HVNGDVTMKL
     PFSIPKQFRE PIMENLQRPS ETLKKDRGHQ RMEPLQHKDI TYARSATSPE NGPRPLKGFS
     DRPSSSSARV PQEPHRQPSS TQNSRKTNTS QGHFDQESRH EQWDKGAGSR NKYKPAWRPI
     REVLNVDTVL NELEQRRQQQ QDSPRCSKTV SQERGRPDQR VCTHEYAQTA DERKQKYLMT
     IYEEEHRQKS DSHSSVESES KLSQQRNSRL KGCSKALLRS DTWTIQRTES GYESSDRLSS
     GSTNPDSPGV DGFGIRPDQR STPDVQSQLN QKGVNTKTSI TSSPPHNGKH QPRPQGKKYD
     QPTISHQKFS PCSRRKSKYG STSRKEKTFA GSENRQTELQ ELTNFRPHSV ESSTLKQITK
     TSSSEWNSSD DLALSESEDR ESTYLSSNSE AVSSDSQCPQ ISLQYHPNNG PAEALLPDSQ
     HQLGPTGSPN LRPSQRMSQQ GEASHGFNSR MLQEPFSSSP HLSSTYYFSP HRKPDMSGLR
     TFSDASSKSG SDPERSTQSS CESEERLAGG KAEQAAPAQE VSLTTYFNVD NCMTETYRLK
     YHNQRPLVLS ATVPRTAAVS ERRENSQANP NDSHSQDVPK AKPETSHNSN KPTAKWNPVT
     TKGLDERGFL
//