ID A0A3B3BTN7_ORYME Unreviewed; 843 AA.
AC A0A3B3BTN7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Rho guanine nucleotide exchange factor 7-like {ECO:0000313|Ensembl:ENSOMEP00000008408.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000008408.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000008408.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
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DR AlphaFoldDB; A0A3B3BTN7; -.
DR STRING; 30732.ENSOMEP00000008408; -.
DR PaxDb; 30732-ENSOMEP00000008408; -.
DR Ensembl; ENSOMET00000002499.1; ENSOMEP00000008408.1; ENSOMEG00000009571.1.
DR GeneTree; ENSGT00940000155360; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11877; SH3_PIX; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..111
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 161..220
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 249..429
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 451..556
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 556..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 791..832
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 568..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 94618 MW; 99FE79C91393E161 CRC64;
MNPAEQTVTW LITLGVLDSP KKSVSDPEAF LQTSLRDGAV LCRLLERLRP GTVDRFFQEP
RSDSDFQKNI AEFLKGLAAF GVEPFEVSDL LQGLNFSKVL NSLVALNKAT EGVGVSGDGG
GVPHSSGSRI KSFDSLNTQG RSSKLLLPQY RSLDMSEGSG CGQLLVKARF PFQQTNEDEL
SFSKGDVIVV RRQEEGGWWE GSLNGKTGWF PSNYVRELKG CDKTADKPKS GTLKSPPKGF
DTSIISKTYY NVVLQNILEA ETEYSRELQS LLGSYLRSLQ PTDRLSSGDI NHIQANLEEI
STFQQMLVQS LDEQTKLPEH QQRIGGFFLS LMPQMKTIYV SYCSNHPSAV SVLTQHSEEL
GGFMESKGAS SPGILALTTS LSRPFTRLER YPALLKELER HMEEQHPDRA DLHAVMAAFK
HLAAECQEVR KKKDLELQIL TEPIRNWEGD DIKTLGAVLH MSQVTVHSQN CQEVNERFLV
LFPHTLLMLS ASLRMSGFIY QGRIPLSGML ISRIEDGENL RNAFEISGGQ CERMQVACNS
QRDLQDWLDL LTKHTHTPAH PHRPSCHTLP THTVTSSRHS DARGGSSAYH TLPHLSSYES
VTPTWGPLEP PSTPKPWSLS CLRPAPPLRP SAALCFKEDM SKSPKNMKKL LPKRKPERKP
SEEDFTVRKS TAALEEDAQI LKVIEAYCTS AKTRQTLNST WQGTDLMHNH VLADSSLAPA
GLPGNQPCSD QSEDSDYDSI WTAHSHRTAS FSRSSRKDVQ MLFPEEEKII VEETRSNGQT
VVEERSLVDT VYSLKDEVQE LKQDNKRMKR TLEEEQRARK ELERIVRRVL KNMNDPTWDE
TNL
//
