ID A0A3B3BTR0_ORYME Unreviewed; 837 AA.
AC A0A3B3BTR0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Extracellular calcium-sensing receptor-like {ECO:0000313|Ensembl:ENSOMEP00000008955.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000008955.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000008955.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3B3BTR0; -.
DR Ensembl; ENSOMET00000001589.1; ENSOMEP00000008955.1; ENSOMEG00000010205.1.
DR GeneTree; ENSGT01050000244874; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR CDD; cd06364; PBP1_CaSR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061:SF528; C-FAMILY ODORANT RECEPTOR OLFCD2-RELATED; 1.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 607..628
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 640..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 685..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 728..751
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 763..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..819
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 570..833
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 837 AA; 92588 MW; 8A9215845ED2A20C CRC64;
MAIHVIHVYF LFFLYVFVLL KLYGTKFPLL FKSGDIMIGG AFFVHSQVSA SSVTSSDAPD
PLICTRLNFR EFRFAQTMIF AIEEINNSSS LLPNISVGYK IFDSCGSTLP STRAALGLIN
GQERTFGKSC SGQSTVHAIV GATKSSSTIV LSQIAGIFQI PVISHFSTCA CLSNRKEHPS
FFRTIPSDYY QSRALAQLVK HFGWTWVGAV RSDNDYGNNG MATFIEAATQ EGICVEYSEA
ISWTSLDEQV ERVVRVIKTG TAKVVVAFLG YDEMDILLEE ALRQNITGLQ WVGSESWITS
SNLALRKYSG ILTGSIGFAI KKAKIAGLQE FLLQVHPSQD PQNHILREFW EETFGCSFQP
SLQGVKQCSG SERLRDIKNP FTDVSELRIS NNVYKAVYAV AHAMHSMLKC GEKSEEVNMS
CTWKSILPPK EDVNFSLQSG EKVYFDERGD PPATYQLVNW QKNSAGDTVF VTVGSYDASL
PDGKQFTIKE MNLTWPISVC SESCFPGFRQ AVIKGKPICC FSCIACAAGE ISNSTNSAEC
SPCPLEYWSN EDHNKCVPKV IEFLSYEETM GALLAGFSLF GASLTLVVSF VFFWFRHTPL
VKASNSELSF LLLLSLTLCF LCALTFIGQP TDWSCMLRHV AFGITFALCI SCILTKTITV
VIAFTAKRPA NTVPQCSVLL QRMGVLGGTF LQVLICVVWL TLAPPFPHKN TVYAAERIIL
ECSLGSSIGF WVVLGYIGLL AVLCLILAFL ARKLPDNFNE AKFITFSMLI FIAVWVTFIP
AYVSSPGKFT VAVEIFAILA SSFGLLFCIF APKCYILLLK PERNTKNHMM GRNQVKT
//
